AVIAN Behavioural Genomics and Physiology, IFM Biology, Linköping University, Linköping, Sweden.
Respir Physiol Neurobiol. 2011 Aug 31;178(1):75-83. doi: 10.1016/j.resp.2011.03.031. Epub 2011 Apr 5.
The baroreflex is the main short term compensatory mechanism to buffer blood pressure changes and maintain circulatory homeostasis. Its ontogeny and importance during prenatal life is not fully understood so we used broiler chickens to investigate the maturation of the baroreflex in late incubation using a novel method that measured changes in heart rate during spontaneous fluctuations in blood pressure. Our results suggest that a baroreflex is already functional at d17 with no indication of further maturation in terms of sensitivity (gain at 17 d was 52.9±8.3 and at 20 d 69.5±16.2 ms kPa(-1)). The physiological relevance of these values is shown using data surrogation methods. Although the results contrast with the progressive baroreflex maturation indicated by the pharmacological method, we sustain that both methods provide information on baroreflex regulation. While the spontaneous method evaluates truly physiological (but small) pressure changes, the pharmacological method provides a more consistent and repetitive challenge for the reflex that requires a different recruitment of baroreflex effectors.
压力反射是缓冲血压变化和维持循环内稳态的主要短期代偿机制。其在产前生命中的发生和重要性尚未完全被理解，因此我们使用肉鸡来研究在孵化后期压力反射的成熟情况，使用一种新的方法来测量血压自发波动期间心率的变化。我们的结果表明，在 d17 时已经存在压力反射功能，在敏感性方面没有进一步成熟的迹象（17 日的增益为 52.9±8.3，20 日的增益为 69.5±16.2 ms kPa(-1)）。使用数据替代方法显示了这些值的生理相关性。尽管这些结果与药理学方法所表明的压力反射逐渐成熟相矛盾，但我们认为这两种方法都提供了有关压力反射调节的信息。虽然自发方法评估的是真正的生理（但较小）的压力变化，但药理学方法为反射提供了更一致和重复的挑战，需要不同的压力反射效应器招募。
