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柚皮素对转化生长因子-β配体-受体结合抑制作用的单分子研究。

A single-molecule study of the inhibition effect of Naringenin on transforming growth factor-β ligand-receptor binding.

机构信息

Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Key Laboratory of Molecular Nanostructures and Nanotechnology, Chinese Academy of Sciences, Beijing 100190, PR China.

出版信息

Chem Commun (Camb). 2011 May 21;47(19):5440-2. doi: 10.1039/c1cc10778j. Epub 2011 Apr 8.

DOI:10.1039/c1cc10778j
PMID:21475751
Abstract

With single-molecule fluorescence imaging and single-molecule force measurement, we have found that the natural compound Naringenin exerts an inhibition effect on TGF-β ligand-receptor interaction, the initial step of TGF-β signaling.

摘要

通过单分子荧光成像和单分子力测量，我们发现天然化合物柚皮素对 TGF-β 配体-受体相互作用（TGF-β 信号转导的初始步骤）具有抑制作用。

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