Protein & Peptide Pharmaceutical Laboratory, National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Protein Cell. 2011 Jun;2(6):507-16. doi: 10.1007/s13238-011-1056-8. Epub 2011 Jul 12.
Metastasis is the main cause of death in cancer patients. To improve the outcomes of patients undergoing a surgery, new adjuvant therapies that can effectively inhibit metastases have to be developed. Studies have shown that flavonoid naringenin, a natural product that is mainly present in grapes and citrus, may contribute to cancer prevention. It has many advantages compared to traditional chemotherapeutic drugs, such as low toxicity. To determine whether naringenin can also inhibit metastases, a breast cancer resection model that mimics clinical situations was established. We found that orally administered naringenin significantly decreased the number of metastatic tumor cells in the lung and extended the life span of tumor resected mice. Flow cytometry analysis revealed that T cells displayed enhanced antitumor activity in naringenin treated mice, with an increased proportion of IFN-γ and IL-2 expressing T cells. In vitro studies further demonstrated that relief of immunosuppression caused by regulatory T cells might be the fundamental mechanism of metastasis inhibition by naringenin. These results indicate that orally administered naringenin can inhibit the outgrowth of metastases after surgery via regulating host immunity. Thus, naringenin can be an ideal surgical adjuvant therapy for breast cancer patients.
转移是癌症患者死亡的主要原因。为了改善接受手术治疗的患者的预后，必须开发新的辅助治疗方法，以有效抑制转移。研究表明，类黄酮柚皮素是一种主要存在于葡萄和柑橘类水果中的天然产物，可能有助于预防癌症。与传统的化疗药物相比，它具有许多优势，例如低毒性。为了确定柚皮素是否也能抑制转移，建立了一种模拟临床情况的乳腺癌切除术模型。我们发现，口服柚皮素可显著减少肺转移肿瘤细胞的数量，并延长肿瘤切除小鼠的寿命。流式细胞术分析显示，柚皮素处理的小鼠中 T 细胞显示出增强的抗肿瘤活性，表达 IFN-γ 和 IL-2 的 T 细胞比例增加。体外研究进一步表明，缓解调节性 T 细胞引起的免疫抑制可能是柚皮素抑制转移的根本机制。这些结果表明，口服柚皮素可通过调节宿主免疫来抑制手术后转移的生长。因此，柚皮素可以成为乳腺癌患者理想的手术辅助治疗方法。
