铜催化的脂肪醛α-胺化反应。
Copper-catalyzed α-amination of aliphatic aldehydes.
机构信息
Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637616.
出版信息
Chem Commun (Camb). 2011 May 21;47(19):5458-60. doi: 10.1039/c1cc11102g. Epub 2011 Apr 8.
PMID:21475752
Abstract
A highly efficient copper-catalyzed α-amination of aliphatic aldehydes for the synthesis of α-amino acetals using secondary amines with readily removable protecting groups as a nitrogen source was developed. This reaction can be operated under very mild conditions, affording the desired products in moderate to good yields.
摘要
发展了一种高效的铜催化脂肪醛的α-胺化反应，使用具有易去除保护基的仲胺作为氮源合成α-氨基缩醛。该反应可以在非常温和的条件下进行，以中等至良好的收率得到所需产物。
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