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Phospholipid binding lowers immunogenicity of human recombinant factor VIII in von Willebrand factor knockout mice.

作者信息

Pisal D S, Balu-Iyer S V

出版信息

Thromb Haemost. 2011 Jun;105(6):1115-8. doi: 10.1160/TH10-09-0628. Epub 2011 Apr 7.

Abstract
摘要

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引用本文的文献

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Native-like aggregates of factor VIII are immunogenic in von Willebrand factor deficient and hemophilia a mice.
J Pharm Sci. 2012 Jun;101(6):2055-65. doi: 10.1002/jps.23091. Epub 2012 Mar 2.

本文引用的文献

1
Endocytic receptor for pro-coagulant factor VIII: relevance to inhibitor formation.
Thromb Haemost. 2010 Dec;104(6):1093-8. doi: 10.1160/TH10-05-0294. Epub 2010 Sep 30.
2
Phospholipid binding improves plasma survival of factor VIII.
Thromb Haemost. 2010 Nov;104(5):1073-5. doi: 10.1160/TH10-06-0422. Epub 2010 Sep 13.
4
Improvements in factor VIII inhibitor detection: From Bethesda to Nijmegen.
Semin Thromb Hemost. 2009 Nov;35(8):752-9. doi: 10.1055/s-0029-1245107. Epub 2010 Feb 18.
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A role for thrombin in the initiation of the immune response to therapeutic factor VIII.
Blood. 2009 Nov 19;114(21):4741-8. doi: 10.1182/blood-2008-10-186452. Epub 2009 Sep 30.
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Recombinant and plasma-derived factor VIII products induce distinct splenic cytokine microenvironments in hemophilia A mice.
Blood. 2009 Jul 23;114(4):871-80. doi: 10.1182/blood-2008-09-174649. Epub 2009 May 1.
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B-cell and T-cell epitopes in anti-factor VIII immune responses.
Clin Rev Allergy Immunol. 2009 Oct;37(2):80-95. doi: 10.1007/s12016-009-8120-7.
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The role of VWF in the immunogenicity of FVIII.
Thromb Res. 2008;122 Suppl 2:S3-6. doi: 10.1016/S0049-3848(08)70002-1.
9
Factor VIII inhibitors: role of von Willebrand factor on the uptake of factor VIII by dendritic cells.
Haemophilia. 2007 Dec;13 Suppl 5:61-4. doi: 10.1111/j.1365-2516.2007.01575.x.

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