对于胎儿纤连蛋白呈阳性的高危无症状女性，治疗细菌性阴道病并不能降低早产风险。

Treatment of bacterial vaginosis does not reduce preterm birth among high-risk asymptomatic women in fetal fibronectin positive patients.

作者信息

Briery Christian M, Chauhan Suneet P, Magann Everett F, Cushman Julie L, Morrison John C

机构信息

Willis Knighton Health System, 9111 Susan Drive, Shreveport, LA 71118, USA.

出版信息

J Miss State Med Assoc. 2011 Mar;52(3):72-5.

PMID:21476464

Abstract

OBJECTIVE

Bacterial vaginosis (BV) is associated with preterm labor and may be positive in 15% of asymptomatic high-risk women. Fetal fibronectin (fFN) has been shown in symptomatic women to predict infection-related preterm birth. The purpose of this study was to quantitate the relationship between BV/fFN and preterm delivery in high-risk asymptomatic women.

METHODS

Women at high-risk for spontaneous preterm delivery were tested for BV/fFN between 20-28 weeks gestation. Women positive for BV were treated with metronidazole, and fFN results were not used by physicians in treatment. After delivery, test results and pregnancy outcomes were entered in a deidentified database and analyzed.

RESULTS

Of 232 women tested for BV/fFN over a 24-month epoch, results divided participants into 4 groups: Group A (N = 12; +BV/+fFN); Group B (N = 22; -BV/+fFN); Group C (N = 68; +BV/-fFN); and Group D (N = 130; -BV/-fFN). Demographics were the same between the 4 groups (P = NS) as was the gestational age at delivery (36.41 +/- 3.96 to 37.18 +/- 3.03 weeks). The incidence ofpreterm labor (P = .075), spontaneous early delivery (P = .936) and infants < 2500 gm (P = .664) was also similar.

CONCLUSIONS

In asymptomatic high-risk women, testing for fFN/BV during mid-pregnancy does not appear warranted.

摘要

目的

细菌性阴道病（BV）与早产相关，在15%无症状高危女性中可能呈阳性。胎儿纤连蛋白（fFN）已被证实在有症状的女性中可预测感染相关的早产。本研究的目的是量化高危无症状女性中BV/fFN与早产之间的关系。

方法

对有自发早产风险的女性在妊娠20 - 28周时进行BV/fFN检测。BV检测呈阳性的女性用甲硝唑治疗，医生在治疗中不使用fFN检测结果。分娩后，将检测结果和妊娠结局录入一个去识别化的数据库并进行分析。

结果

在24个月期间对232名女性进行了BV/fFN检测，结果将参与者分为4组：A组（N = 12；BV阳性/fFN阳性）；B组（N = 2；BV阴性/fFN阳性）；C组（N = 68；BV阳性/fFN阴性）；D组（N = 130；BV阴性/fFN阴性）。4组之间的人口统计学特征相同（P =无显著性差异），分娩时的孕周也相同（36.41±3.96至37.18±3.03周）。早产（P = 0.075）、自发早产（P = 0.936）和出生体重<2500克的婴儿（P = 0.664）的发生率也相似。