Samad Rozanah Asmah Abdul, Nomura Naoki, Tsuda Yoshimi, Manzoor Rashid, Kajihara Masahiro, Tomabechi Daisuke, Sasaki Takashi, Kokumai Norihide, Ohgitani Toshiaki, Okamatsu Masatoshi, Takada Ayato, Sakoda Yoshihiro, Kida Hiroshi
Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan.
Jpn J Vet Res. 2011 Feb;59(1):23-9.
Inactivated influenza virus vaccine prepared from a non-pathogenic influenza virus strain A/duck/Hokkaido/Vac-1/2004 (H5N1) from the virus library conferred protective immunity to chickens against the challenge of antigenically drifted highly pathogenic avian influenza virus (HPAIV), A/whooper swan/Hokkaido/1/2008 (H5N1). The efficacy of the vaccine was comparable to that prepared from genetically modified HPAIV strain deltaRRRRK rg-A/ whooper swan/Mongolia/3/2005 (H5N1), which is more antigenically related to the challenge virus strain, in chickens.
从病毒库中一株非致病性甲型流感病毒A/鸭/北海道/Vac-1/2004（H5N1）制备的灭活流感病毒疫苗，可使鸡对抗原性发生漂移的高致病性禽流感病毒（HPAIV）A/大天鹅/北海道/1/2008（H5N1）的攻击产生保护性免疫。在鸡中，该疫苗的效力与用基因改造的HPAIV毒株deltaRRRRK rg-A/大天鹅/蒙古/3/2005（H5N1）制备的疫苗相当，后者与攻击病毒株的抗原关系更为密切。
