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H5和H7流感病毒疫苗株的研发

Development of vaccine strains of H5 and H7 influenza viruses.

作者信息

Soda Kosuke, Sakoda Yoshihiro, Isoda Norikazu, Kajihara Masahiro, Haraguchi Yoshinari, Shibuya Hitomi, Yoshida Hiromi, Sasaki Takashi, Sakamoto Ryuichi, Saijo Kazue, Hagiwara Junko, Kida Hiroshi

机构信息

Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, 060-0818, Japan.

出版信息

Jpn J Vet Res. 2008 Jan;55(2-3):93-8.

PMID:18318111
Abstract

To establish vaccine strains of H5 and H7 influenza viruses, A/duck/Hokkaido/Vac-1/04 (H5N1) [Vac-1/04 (H5N1)], A/duck/Hokkaido/Vac-3/07 (H5N1) [Vac-3/07 (H5N1)], and A/duck/Hokkaido/ Vac-2/04 (H7N7) [Vac-2/04 (H7N7)] were generated from non-pathogenic avian influenza viruses isolated from migratory ducks. Vac-1/04 (H5N1) and Vac-3/07 (H5N1) were generated by genetic reassortment between H5N2 or H5N3 virus as an HA gene provider and H7N1 or H6N1 viruses as an NA gene provider. Vac-2/04 (H7N7) was a genetic reassortant obtained using H7N7 and H9 N2 viruses to give high growth character of the H9N2 virus in chicken embryonated eggs. The results of sequence analyses and experimental infections revealed that these H5N1 and H7N7 reassortant viruses were non-pathogenic in chickens and embryos, and had good growth potential in embryonated eggs. These viruses should be useful to develop vaccines against H5 and H7 highly pathogenic avian influenza viruses.

摘要

为建立H5和H7流感病毒疫苗株，从迁徙鸭中分离出的非致病性禽流感病毒培育出了A/鸭/北海道/Vac - 1/04（H5N1）[Vac - 1/04（H5N1）]、A/鸭/北海道/Vac - 3/07（H5N1）[Vac - 3/07（H5N1）]和A/鸭/北海道/Vac - 2/04（H7N7）[Vac - 2/04（H7N7）]。Vac - 1/04（H5N1）和Vac - 3/07（H5N1）是通过以H5N2或H5N3病毒作为HA基因供体与H7N1或H6N1病毒作为NA基因供体进行基因重配产生的。Vac - 2/04（H7N7）是使用H7N7和H9N2病毒获得的基因重配体，以使H9N2病毒在鸡胚中具有高生长特性。序列分析和实验感染结果表明，这些H5N1和H7N7重配病毒对鸡和胚胎无致病性，并且在鸡胚中具有良好的生长潜力。这些病毒对于开发针对H5和H7高致病性禽流感病毒的疫苗应该是有用的。

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