Carmines P K, Fleming J T
Department of Physiology, Tulane University School of Medicine, New Orleans, Louisiana 70112.
FASEB J. 1990 Dec;4(15):3300-9. doi: 10.1096/fasebj.4.15.2147667.
In recent years, numerous techniques have been developed to study renal microcirculation. These technical advances have provided new insight regarding the specificity of action of vasoconstrictor peptides (angiotensin II, arginine vasopressin, endothelin) and vasodilator peptides (bradykinin, atrial natriuretic peptide) at discrete sites within the renal vascular bed. Differential signal transduction mechanisms, particularly those related to calcium regulation, appear to mediate the renal vascular actions of these compounds, both in a segment-specific and agonist-specific manner. These observations substantiate the concept that regulation of intrarenal and intraglomerular dynamics is accomplished by selective changes in pre- and postglomerular resistance induced by different endogenous peptides. This microvascular selectivity allows precise regulation of glomerular and peritubular capillary function, and ultimately exerts great influence on the volume and composition of the final urine.
近年来，已经开发出许多技术来研究肾微循环。这些技术进步为血管收缩肽（血管紧张素II、精氨酸加压素、内皮素）和血管舒张肽（缓激肽、心房利钠肽）在肾血管床内离散部位的作用特异性提供了新的见解。差异信号转导机制，特别是那些与钙调节相关的机制，似乎以节段特异性和激动剂特异性的方式介导这些化合物的肾血管作用。这些观察结果证实了这样一种概念，即肾内和肾小球内动力学的调节是通过不同内源性肽诱导的肾小球前和肾小球后阻力的选择性变化来实现的。这种微血管选择性允许精确调节肾小球和肾小管周围毛细血管的功能，并最终对最终尿液的体积和成分产生重大影响。
