用西那卡塞、帕立骨化醇和自体生长因子治疗钙化性尿毒症性小动脉病。
Calcific uremic arteriolopathy treated with cinacalcet, paricalcitol, and autologous growth factors.
机构信息
Department of Plastic and Reconstructive Surgery, Democritus University Hospital, Alexandrouplois, Greece.
出版信息
J Cutan Med Surg. 2011 Mar-Apr;15(2):121-4. doi: 10.2310/7750.2011.10052.
BACKGROUND
Calcific uremic arteriolopathy is an uncommon cutaneous ischemic necrotizing disease, most commonly associated with renal disease and hyperparathyroidism, bearing a high mortality rate.
OBJECTIVE AND METHOD
A case of a 57-year-old female renal patient with hyperparathyroidism who was successfully treated with combined paricalcitol and cinacalcet systemically, while autologous growth factors were locally applied, is herein presented.
RESULT AND CONCLUSION
The combination of cinacalcet and paricalcitol is a reliable alternative to parathyroidectomy in patients with calcific uremic arteriolopathy and hyperparathyroidism. Meticulous débridement of necrotic tissues is essential and application of autologous growth factors promotes healing.
背景
钙化性尿毒症性小动脉病是一种罕见的皮肤缺血性坏死性疾病，最常与肾脏疾病和甲状旁腺功能亢进症相关，死亡率高。
目的与方法
本文报告了一例 57 岁女性肾性甲状旁腺功能亢进症患者，该患者成功接受了帕立骨化醇和西那卡塞联合全身治疗，同时局部应用了自体生长因子。
结果与结论
在患有钙化性尿毒症性小动脉病和甲状旁腺功能亢进症的患者中，西那卡塞和帕立骨化醇的联合治疗是甲状旁腺切除术的一种可靠替代方法。仔细清创坏死组织是必不可少的，应用自体生长因子可促进愈合。
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