Florey Neuroscience Institutes, The University of Melbourne, Parkville, Victoria 3010, Australia.
Steroids. 2011 Jul;76(8):816-9. doi: 10.1016/j.steroids.2011.02.031. Epub 2011 Apr 6.
Oestrogens regulate normal behaviour and have been implicated in modulating pathological behaviour such as obsessive compulsive disorder and neurological disorder such as Parkinsonism. Therefore, by regulating the expression of the oestrogen-synthesising enzyme, aromatase, we may identify what behaviour is regulated by oestrogen. Inhibition of aromatase either genetically or pharmacologically has been reported to induce sexual behaviour impairment, compulsive behaviour and susceptibility to neurodegeneration.
雌激素调节正常行为，并被认为可以调节病理性行为，如强迫症和神经障碍，如帕金森病。因此，通过调节雌激素合成酶芳香化酶的表达，我们可以确定雌激素调节哪些行为。已经有报道称，通过基因或药物抑制芳香化酶会导致性行为障碍、强迫行为和易患神经退行性疾病。
