基于高分辨率晶体学研究的抗体结构分析。

Analysis of the antibody structure based on high-resolution crystallographic studies.

机构信息

The Marine Science Institute, University of the Philippines Diliman, Quezon City 1101, Philippines.

出版信息

N Biotechnol. 2011 Sep;28(5):435-47. doi: 10.1016/j.nbt.2011.03.012. Epub 2011 Apr 6.

DOI:10.1016/j.nbt.2011.03.012

Abstract

High-resolution structures of liganded and unliganded antibody molecules were analyzed in terms of the interaction between the antibody with ligand, between the residues in the contact between the variable domains, and between the framework and the complementarity-determining regions of the antibody. The solvent accessibilities of the residues in the variable domains were also analyzed. The structural information is useful in the engineering of antibodies for therapeutic and other purposes.

摘要

高分辨率的配体结合和非配体结合抗体分子结构，分析了抗体与配体之间的相互作用、可变域之间的接触残基之间的相互作用、以及抗体的框架和互补决定区之间的相互作用。还分析了可变域中残基的溶剂可及性。这些结构信息可用于治疗和其他目的的抗体工程。