[Participation of prostaglandins in the mechanism of hypothalamo-hypophyseal regulation of thyroid gland function].

Prostaglandins E (PGE) content was studied in the hypothalamus, hypophysis, thyroid gland and blood of rats after thyroliberin injections, thyrotropin administration, and thyroidectomy in experimental hyperthyroidism. Changes in the PGE level, cyclic adenosine monophosphate (cAMP), and in thyroxin secretion in the thyroid gland of man under the effect of thyrotropin and acetylsalicyclic acid were studied. The effect of acetylsalicylic acid on thyroxin and triiodothyronine secretion in healthy persons and those suffering from thyrotoxicosis was investigated. Analysis of the results obtained indicated that PGE played a significant role in the mechanism of the thyroid gland function regulation.