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[三碘甲状腺原氨酸甲状腺毒症的诊断]

[Diagnosis of triiodothyronine thyrotoxicosis].

作者信息

Semenov V D

出版信息

Probl Endokrinol (Mosk). 1982 Nov-Dec;28(6):32-5.

PMID:6818538
Abstract

The effectiveness and safety of different methods of radioimmunoassay to determine the thyroid function were studied in 298 patients: 172 with nodose toxic goiter and 116 with nodose euthyroid goiter. A "warm", "hot", "cold" and "autonomic" nodes, respectively, prevailed in nodose goiter, on skanning. Free triiodothyronine index and elevated serum triiodothyronine index (EST3I) were calculated to determine the effect of thyroxin-binding ability of globulin on the total triiodothyronine level. Three types of thyrotoxicosis (T3/4-, T3- and T4-thyrotoxicosis) were found as a result of using complex methods to record the tests, showing a functional state of the hypophyseal-thyroid system. A high informativeness of the main thyroid tests was detected, i.e. determination of the total thyroxin, serum triiodothyronine and thyroxin efficiency coefficient. EST3I has the most diagnostic significance, being especially valuable in T3-thyrotoxicosis detection.

摘要

对298例患者研究了不同放射免疫测定方法检测甲状腺功能的有效性和安全性,其中172例为结节性毒性甲状腺肿患者,116例为结节性甲状腺功能正常患者。扫描显示,结节性甲状腺肿中分别以“温”、“热”、“冷”和“自主性”结节为主。计算游离三碘甲状腺原氨酸指数和血清三碘甲状腺原氨酸升高指数(EST3I),以确定球蛋白的甲状腺素结合能力对总三碘甲状腺原氨酸水平的影响。采用综合方法记录检测结果,发现了三种类型的甲状腺毒症(T3/4-型、T3-型和T4-型甲状腺毒症),显示了垂体-甲状腺系统的功能状态。检测发现主要甲状腺检测项目具有较高的信息量,即总甲状腺素、血清三碘甲状腺原氨酸和甲状腺素效率系数的测定。EST3I具有最大的诊断意义,在检测T3-型甲状腺毒症方面尤其有价值。

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