硼中子俘获疗法治疗局部复发性头颈癌：清华大学开放池式反应堆I/II期试验的初步临床经验
BNCT for locally recurrent head and neck cancer: preliminary clinical experience from a phase I/II trial at Tsing Hua Open-Pool Reactor.
作者信息
Wang L W, Wang S J, Chu P Y, Ho C Y, Jiang S H, Liu Y W H, Liu Y H, Liu H M, Peir J J, Chou F I, Yen S H, Lee Y L, Chang C W, Liu C S, Chen Y W, Ono K
机构信息
Cancer Center, Taipei Veterans General Hospital, Taiwan, ROC.
出版信息
Appl Radiat Isot. 2011 Dec;69(12):1803-6. doi: 10.1016/j.apradiso.2011.03.008. Epub 2011 Mar 30.
To introduce our preliminary experience of treating locally and regionally recurrent Head and Neck cancer patients at Tsing Hua Open-Pool Reactor in Taiwan, four patients (M/F=3/1, median age 68 Y/O) were enrolled. BNCT with BPA (400 mg/kg) injected in 2 phases and prescription dose of 12-35 Gy (Eq.)/fraction for 2 fractions at 30 day interval can be given with sustained blood boron concentration and tolerable early toxicities for recurrent H & N cancer.
为介绍我们在台湾清华开放池式反应堆治疗局部及区域复发性头颈癌患者的初步经验，我们纳入了4例患者（男/女 = 3/1，中位年龄68岁）。对于复发性头颈癌，可分两阶段注射BPA（400 mg/kg）进行硼中子俘获治疗（BNCT），每隔30天给予2次分割剂量为12 - 35 Gy（等效剂量）的处方剂量，可维持血硼浓度且早期毒性耐受。
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