Department of Mechanical Engineering, Galway Medical Technologies Centre (GMedTech), Galway Mayo Institute of Technology (GMIT), Dublin Road, Galway, Ireland.
Med Eng Phys. 2011 Oct;33(8):957-66. doi: 10.1016/j.medengphy.2011.03.005. Epub 2011 Apr 7.
The optimum time to treat abdominal aortic aneurysms (AAAs) still remains an uncertain issue. The decision to intervene does not take in account the effects that wall curvature, intraluminal thrombus (ILT) properties and thickness have on rupture. The role of ILT in aneurysm dynamics and rupture has been controversial. In vitro testing of four silicone AAA models incorporating the ILT and aortic bifurcation was studied under physiological conditions. Pressures (P) and diameters (D) were analysed for models with and without ILT at different locations. The diametral strain, compliance and P/D curves were influenced by the presence, elastic stiffness and thickness of the ILT. In this case, the inclusion of ILT reduced the lumen area by 77% that resulted in a 0.5-81% reduction in compliance depending on ILT properties. With an increase in ILT stiffness from 0.05 to 0.2 MPa, the compliance was reduced by 81%. In the region of maximum diameter, there was a reduction of diametral strain and compliance except for the softer ILT which was more compliant throughout the proximal region. The shifting of the maximum diametral strain and compliance to the proximal neck was pronounced by an increase in ILT stiffness, thus creating a possible rupture site.
治疗腹主动脉瘤（AAA）的最佳时间仍然是一个不确定的问题。干预的决定并没有考虑到管壁曲率、腔内血栓（ILT）性质和厚度对破裂的影响。ILT 在动脉瘤动力学和破裂中的作用一直存在争议。在生理条件下，对包含 ILT 和主动脉分叉的四个硅橡胶 AAA 模型进行了体外测试。分析了有和没有 ILT 的不同位置的模型的压力（P）和直径（D）。有、无 ILT 的情况下，直径应变、顺应性和 P/D 曲线受 ILT 的存在、弹性刚度和厚度的影响。在这种情况下，ILT 的存在使管腔面积减少了 77%，从而使顺应性降低了 0.5-81%，具体取决于 ILT 的性质。随着 ILT 刚度从 0.05 增加到 0.2 MPa，顺应性降低了 81%。在最大直径区域，直径应变和顺应性都降低了，除了更柔软的 ILT，它在整个近端区域都更具顺应性。随着 ILT 刚度的增加，最大直径应变和顺应性向近端颈部转移，从而形成了可能的破裂部位。
