Searle M, Dathan R, Dean S, Christensen C C, Westheim A
Department of Medicine, Royal South Hampshire Hospital, UK.
Eur J Clin Pharmacol. 1990;39(3):299-300. doi: 10.1007/BF00315116.
Doxazosin (mean dose 11 mg) given once daily in combination with 100 mg atenolol (n = 44) was compared with placebo and atenolol (n = 43) in a double-blind, multicenter study in patients with mild to moderate essential hypertension. In the atenolol/doxazosin-treated group, standing blood pressure significantly decreased by 17.0/12.3 mm Hg compared to 6.2/6.7 mm Hg in the atenolol/placebo group whereas supine blood pressure decreased by 13.2/9.8 mm Hg and 9.2/6.0 mm Hg, respectively in the two groups. Serum lipids did not change significantly in either group. The majority of side-effects reported were mild and transient. This study confirms that doxazosin may be safely combined with a beta-blocker. Doxazosin proved to be well tolerated and effective in patients with blood pressure refractory to atenolol alone.
在一项针对轻至中度原发性高血压患者的双盲、多中心研究中，将每日一次给予多沙唑嗪（平均剂量11毫克）联合100毫克阿替洛尔（n = 44）与安慰剂和阿替洛尔（n = 43）进行比较。在阿替洛尔/多沙唑嗪治疗组中，站立位血压显著下降17.0/12.3毫米汞柱，而阿替洛尔/安慰剂组为6.2/6.7毫米汞柱；仰卧位血压在两组中分别下降13.2/9.8毫米汞柱和9.2/6.0毫米汞柱。两组的血脂均无显著变化。报告的大多数副作用为轻度且短暂。本研究证实多沙唑嗪可安全地与β受体阻滞剂联合使用。事实证明，多沙唑嗪在单独使用阿替洛尔血压控制不佳的患者中耐受性良好且有效。
