Lardinois C K, Neuman S L
Veterans Administration Medical Center, Reno, NV 89520.
Arch Intern Med. 1988 Jun;148(6):1280-8.
Hypertension is a major risk factor for arteriosclerotic vascular disease. Despite intensive antihypertensive intervention, the risk of cardiovascular disease has not declined appreciably. Many of the antihypertensive agents have been shown to elevate total serum cholesterol and triglyceride levels or lower the high-density lipoprotein-cholesterol level. Thus, the antihypertensive agents chosen may negate the beneficial effects of a lower blood pressure. Our purpose is to review all available antihypertensive medications and their influence on lipoprotein metabolism. Choosing the antihypertensive therapy least likely to worsen or precipitate other known cardiovascular risk factors is important. Cost and side effect profiles must also be considered in choosing the best antihypertensive regimen for your patients.
高血压是动脉粥样硬化性血管疾病的主要危险因素。尽管进行了强化抗高血压干预，但心血管疾病的风险并未明显下降。许多抗高血压药物已被证明会升高血清总胆固醇和甘油三酯水平，或降低高密度脂蛋白胆固醇水平。因此，所选用的抗高血压药物可能会抵消血压降低带来的有益作用。我们的目的是综述所有可用的抗高血压药物及其对脂蛋白代谢的影响。选择最不可能加重或引发其他已知心血管危险因素的抗高血压治疗方法很重要。在为患者选择最佳抗高血压治疗方案时，还必须考虑成本和副作用情况。
