Fargeas C, Wu C Y, Luo H Y, Sarfati M, Delespesse G, Wu J P
Allergy Research Laboratory, Notre-Dame Hospital Research Centre, University of Montreal, Canada.
J Immunol. 1990 Dec 15;145(12):4053-8.
A biologically active form of vitamin D, 1,25(OH)2D3, and a leukocyte surface molecule, CD23, play important roles in immune regulation. The effect of 1,25(OH)2D3 on the CD23 gene expression was examined in this study. The results show that 1,25(OH)2D3 suppresses spontaneous and IL-4-stimulated CD23 synthesis by peripheral blood monocytes. The inhibition occurs at both the protein and mRNA levels. However, 1,25(OH)2D3 has no inhibitory effect on CD23 production by either resting or activated tonsillar B cells. Our results suggest a possible role of 1,25(OH)2D3 in the regulation of certain immune and inflammatory responses via its effect on CD23 production.
维生素D的一种生物活性形式1,25(OH)₂D₃和一种白细胞表面分子CD23在免疫调节中发挥重要作用。本研究检测了1,25(OH)₂D₃对CD23基因表达的影响。结果表明，1,25(OH)₂D₃可抑制外周血单核细胞自发合成以及IL-4刺激的CD23合成。这种抑制作用在蛋白质和mRNA水平均有发生。然而，1,25(OH)₂D₃对静息或活化的扁桃体B细胞产生CD23没有抑制作用。我们的结果表明，1,25(OH)₂D₃可能通过影响CD23的产生在某些免疫和炎症反应的调节中发挥作用。
