用血管紧张素转换酶特异性抗体逆转肾血管性高血压。
Reversal of renovascular hypertension by antibodies specific for angiotensin-converting enzyme.
作者信息
Markle R A, Sonnenblick E H, Conroy J M, Soffer R L
出版信息
Proc Natl Acad Sci U S A. 1978 Nov;75(11):5702-5. doi: 10.1073/pnas.75.11.5702.
Goat antibodies developed against pure rabbit pulmonary angiotensin-converting enzyme (peptidyl dipeptidase, EC 3.4.15.1) were administered intravenously to rats with two-kidney Goldblatt hypertension and to normotensive animals. In the hypertensive model these antibodies were associated with a sustained, immune-dependent decrease of blood pressure to normal values. A smaller, but also immune-specific, reduction of blood pressure was observed in the normotensive group. The data suggest that heterologous antibody directed against angiotensin-converting enzyme may provide a biologically specific probe for examining the contribution of the renin-angiotensin system to normal and pathologic circulatory states.
将针对纯兔肺血管紧张素转换酶（肽基二肽酶，EC 3.4.15.1）制备的山羊抗体静脉注射到双肾 Goldblatt 高血压大鼠和正常血压动物体内。在高血压模型中，这些抗体与血压持续、免疫依赖性降低至正常水平有关。在正常血压组中观察到较小但同样具有免疫特异性的血压降低。数据表明，针对血管紧张素转换酶的异源抗体可能为研究肾素-血管紧张素系统对正常和病理循环状态的作用提供一种生物学特异性探针。
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