血管紧张素II的纯化
The purification of hypertensin II.
作者信息
SKEGGS L T, KAHN J R, SHUMWAY N P
出版信息
J Exp Med. 1956 Mar 1;103(3):301-7. doi: 10.1084/jem.103.3.301.
Abstract
The enzymatic conversion of hypertensin I to hypertensin II is described together with the subsequent purification of the product by means of counter-current distribution. Improved methods are also presented for the preparation of renin and its substrate, as well as in methods for the reaction of these materials and the purification of the resulting hypertensin I.
摘要
文中描述了血管紧张素I向血管紧张素II的酶促转化过程，以及随后通过逆流分配法对产物进行纯化的方法。还介绍了制备肾素及其底物的改进方法，以及这些物质的反应方法和所得血管紧张素I的纯化方法。
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本文引用的文献
1
STUDIES ON EXPERIMENTAL HYPERTENSION : XXI. THE PURIFICATION OF RENIN.实验性高血压研究：二十一、肾素的提纯。
J Exp Med. 1943 Jul 1;78(1):67-74. doi: 10.1084/jem.78.1.67.
2
THE RENAL HUMORAL PRESSOR MECHANISM IN MAN. I. PREPARATION AND ASSAY OF HUMAN RENIN, HUMAN HYPERTENSINOGEN, AND HYPERTENSIN.人类的肾素 - 血管紧张素升压机制。一、人肾素、人血管紧张素原及血管紧张素的制备与测定
J Clin Invest. 1945 Jan;24(1):62-8. doi: 10.1172/JCI101579.
3
The assay of hypertensin from the arterial blood of normotensive and hypertensive human beings.对正常血压和高血压人群动脉血中高血压素的测定。
J Exp Med. 1952 Jun;95(6):523-9. doi: 10.1084/jem.95.6.523.
4
The isolation and assay of hypertensin from blood.从血液中分离和测定高血压素。
J Exp Med. 1952 Mar;95(3):241-6. doi: 10.1084/jem.95.3.241.
5
The preparation and function of the hypertensin-converting enzyme.血管紧张素转换酶的制备与功能。
J Exp Med. 1956 Mar 1;103(3):295-9. doi: 10.1084/jem.103.3.295.
6
Amino acid composition and electrophoretic properties of hypertensin I.血管紧张素I的氨基酸组成和电泳特性。
J Exp Med. 1955 Oct 1;102(4):435-40. doi: 10.1084/jem.102.4.435.
7
The purification of hypertensin I.血管紧张素I的纯化
J Exp Med. 1954 Oct 1;100(4):363-70. doi: 10.1084/jem.100.4.363.
8
The existence of two forms of hypertensin.高血压素两种形式的存在。
J Exp Med. 1954 Mar;99(3):275-82. doi: 10.1084/jem.99.3.275.
9
A method of assaying small amounts of hypertensin.一种检测少量高血压素的方法。
Lab Invest. 1953 Mar-Apr;2(2):109-14.
10
Countercurrent distribution.逆流分布
Methods Med Res. 1952;5:3-24.
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