Department of Pharmacology and Toxicology, Tehran University of Medical Sciences, Tehran, Iran.
J Nat Med. 2011 Jul;65(3-4):519-25. doi: 10.1007/s11418-011-0533-y. Epub 2011 Apr 11.
Time-dependent effects of ethanolic extract of Boswellia papyrifera, administered systemically, on spatial memory retention in the Morris water maze were investigated in male rats. A total extract of Boswellia papyrifera (300 mg/kg) was administered every eight hours to three groups of rats by gavage for 1, 2 and 4 weeks. In a separate set of experiments, three doses of a fraction of the extract, called the boswellic acids (100, 200 and 300 mg/kg) were administered by gavage to three groups of rats three times a day for 2 weeks. Following these applications, animals were trained for 4 days. Behavioral testing for evaluation of spatial memory retention was performed 48 h after completion of training. Boswellia papyrifera extracts and boswellic acids caused a significant reduction in escape latency and distance traveled but had no influence on swimming speed. These findings provide evidence that Boswellia papyrifera extracts affect spatial memory retention irrespective of the treatment period. In addition our data show that systemic administration of the boswellic acids fraction enhanced spatial memory retention in a dose-dependent manner. These improving effects may be due to some extent to the interactions of these products with inflammatory mediators, neurotransmitter signaling cascades or protein kinase pathways in the brain.
研究了系统给予乳香树乙醇提取物对雄性大鼠在 Morris 水迷宫中空间记忆保留的时程依赖性影响。通过灌胃，将乳香树的总提取物（300mg/kg）每天分三次给予三组大鼠，持续 1、2 和 4 周。在一组单独的实验中，通过灌胃给予三种提取物的一种馏分，称为乳香酸（100、200 和 300mg/kg），每天三次，持续 2 周。在这些应用之后，动物接受了 4 天的训练。在训练完成后 48 小时进行行为测试，以评估空间记忆保留。乳香树提取物和乳香酸显著降低了逃避潜伏期和行进距离，但对游泳速度没有影响。这些发现提供了证据，证明乳香树提取物无论治疗期如何都能影响空间记忆保留。此外，我们的数据表明，全身性给予乳香酸馏分以剂量依赖性方式增强了空间记忆保留。这些改善作用可能在某种程度上归因于这些产品与大脑中的炎症介质、神经递质信号级联或蛋白激酶途径的相互作用。
