Gawish Zeinab, Gamal Maha, Elberry Dalia Azmy, Hegazy Esraa A, Rashed Laila Ahmed, Hosny Sara Adel, Mehesen Marwa Nagi, ShamsEldeen Asmaa Mohammed
Department of Medical Physiology, Faculty of Medicine, Cairo University, Cairo, Egypt.
Department of Microbiology, Faculty of Medicine, Cairo University, Cairo, Egypt.
Mol Neurobiol. 2025 Aug 8. doi: 10.1007/s12035-025-05261-1.
Consumption of a high-fat diet (HFD) contributes to numerous chronic illnesses, including neurological disorders and gastrointestinal dysfunction. The study design included four groups, each consisting of six rats: the control group was fed regular chow, while groups 2 (HFD 2W), 3 (HFD 4W), and 4 (HFD 8W) were given a 60% HFD for 2, 4, and 8 weeks, respectively. A significant change in the latency to the platform in the water maze, a decrease in the percentage of successful cycles in the Y-maze, and a reduction in the percentage of time spent with the novel object were observed between the baseline and endpoint results in the HFD 4W and HFD 8W groups; notably, this was not the case in the control and HFD 2W groups. Consistent with the increased duration of HFD intake, marked damage to the cortical pyramidal cells as well as the mucosa of the ileum and colon was recorded. The optical density of amyloid deposition was significantly increased in the myenteric plexus before the cerebral cortex. In conclusion, increasing the duration of 60% HFD consumption was associated with significant deterioration of spatial and working memory, an increase in lipid profile, and amyloid deposition in the enteric nervous system, which began even before the observable involvement of the cerebral cortex.
食用高脂肪饮食（HFD）会导致多种慢性疾病，包括神经紊乱和胃肠功能障碍。研究设计包括四组，每组有六只大鼠：对照组喂食常规食物，而第2组（HFD 2周）、第3组（HFD 4周）和第4组（HFD 8周）分别给予60%的HFD，持续2周、4周和8周。在HFD 4周和HFD 8周组的基线和终点结果之间，观察到水迷宫中到达平台潜伏期的显著变化、Y迷宫中成功循环百分比的降低以及与新物体相处时间百分比的减少；值得注意的是，对照组和HFD 2周组并非如此。与HFD摄入时间的延长一致，记录到皮质锥体细胞以及回肠和结肠黏膜有明显损伤。肠肌丛中淀粉样蛋白沉积的光密度在大脑皮层之前显著增加。总之，60% HFD食用时间的增加与空间和工作记忆的显著恶化、脂质水平的升高以及肠神经系统中淀粉样蛋白的沉积有关，甚至在大脑皮层出现明显病变之前就已开始。
