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神经诊断学问题。戈登·摩根·霍姆斯。

Neurognostics question. Gordon Morgan Holmes.

作者信息

Fine Edward J, Mehta Bijal, Lohr Linda A

机构信息

The Jacobs Neurological Institute at Buffalo General Hospital, Buffalo, NY 14206, USA.

出版信息

J Hist Neurosci. 2011 Apr;20(2):151, 170-6. doi: 10.1080/0964704X.2010.545608.

DOI:10.1080/0964704X.2010.545608
PMID:21480038
Abstract

Gordon Morgan Holmes, MD, MRCP was an Irish born neurologist who received his medical education at Trinity College, Dublin, Ireland. He was trained in neuroanatomy and neuropathology at the Senckenberg Institute, Frankfort-Am-Main by Ludwig Edinger. He then returned to serve as a Registrar (House Officer) mentored by Richard Gowers and John Hughlings Jackson at the National Hospital, Queen Square, London. He collaborated with Thomas Granger Stewart in describing the loss of recoil in patients with cerebellar hemispheric tumors in 1904. Volunteering in 1914 for frontline hospital duty, he examined soldiers who had injuries to their occipital area causing hypotonia, dysmetria, staggering gait, and falling to the side ipsilateral to their injured cerebellar hemisphere. Holmes discovered that increasing the pace of the finger-nose manuever and applying slight resistance to a moving limb attenuated the dysmetria. Continuing observation of these patients afforded him to describe the evolution of their injuries to include increasing tremor and decreasing hypotonia. Holmes first attached levers to the limbs of hispatients to record their movements on a moving smoked paper kymograph. In 1939 he published photograh tracings made by low mass minature light bulbs attached to ataxic limbs that showed thehpometira and hypometria of their movements ipsilateral to their damaged cerebellar lobes. Holmes made sigficant contributions to understanding of the physiology of the human cerebellum.

摘要

戈登·摩根·霍姆斯医学博士、皇家内科医师学会会员是一位出生于爱尔兰的神经学家,他在爱尔兰都柏林的三一学院接受医学教育。他在美因河畔法兰克福的森肯贝格研究所接受路德维希·埃丁格的神经解剖学和神经病理学培训。随后他回到伦敦女王广场的国立医院,在理查德·高尔斯和约翰·休林斯·杰克逊的指导下担任住院医生。1904年,他与托马斯·格兰杰·斯图尔特合作,描述了小脑半球肿瘤患者的反弹丧失情况。1914年,他志愿参加前线医院工作,检查了枕部受伤的士兵,这些士兵出现了肌张力减退、辨距不良、蹒跚步态以及向受伤小脑半球同侧摔倒的症状。霍姆斯发现加快指鼻试验的速度并对运动的肢体施加轻微阻力可以减轻辨距不良。对这些患者的持续观察使他能够描述他们损伤的演变情况,包括震颤加剧和肌张力减退减轻。霍姆斯首先在患者的肢体上连接杠杆,以便在移动的烟熏纸记纹鼓上记录他们的动作。1939年,他发表了由安装在共济失调肢体上的低质量微型灯泡拍摄的照片记录,显示了受损小脑叶同侧运动的动作不协调和辨距障碍。霍姆斯对理解人类小脑的生理学做出了重大贡献。

相似文献

1
Neurognostics question. Gordon Morgan Holmes.神经诊断学问题。戈登·摩根·霍姆斯。
J Hist Neurosci. 2011 Apr;20(2):151, 170-6. doi: 10.1080/0964704X.2010.545608.
2
Sir Gordon Morgan Holmes (1876-1965): one of the founders of modern neurology.戈登·摩根·霍姆斯爵士(1876-1965):现代神经病学的奠基人之一。
Neurol Sci. 2018 Jan;39(1):169-171. doi: 10.1007/s10072-017-3180-6. Epub 2017 Nov 7.
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[Dr. John Hughlings Jackson].[约翰·胡克林·杰克逊医生]
Srp Arh Celok Lek. 1997 Nov-Dec;125(11-12):381-6.
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John Hughlings Jackson (1835-1911): An adornment to the London Hospital.约翰·胡林金斯·杰克逊(1835 - 1911):伦敦医院的荣耀。
J Med Biogr. 2015 Feb;23(1):2-8. doi: 10.1177/0967772013479758. Epub 2015 Jan 12.
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The history of the development of the cerebellar examination.小脑检查的发展历程。
Semin Neurol. 2002 Dec;22(4):375-84. doi: 10.1055/s-2002-36759.
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James Taylor (1859-1946): favourite disciple of Hughlings Jackson and William Gowers.詹姆斯·泰勒(1859 - 1946):休林斯·杰克逊和威廉·高尔斯最喜爱的弟子。
J R Coll Physicians Edinb. 2013;43(4):361-5. doi: 10.4997/JRCPE.2013.418.
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Gordon Holmes Lecture: Gordon Holmes and the neurological heritage.戈登·霍姆斯讲座:戈登·霍姆斯与神经学遗产
Brain. 2007 Jan;130(Pt 1):288-98. doi: 10.1093/brain/awl335.
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Sir Gordon Holmes (1876-1965).戈登·霍姆斯爵士(1876 - 1965)。
J Neurol Neurosurg Psychiatry. 2004 Oct;75(10):1502-3. doi: 10.1136/jnnp.2003.016170.
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Jean Martin Charcot (1825-93) and John Hughlings Jackson (1835-1911): neurology in France and England in the 19th century.让·马丁·夏科(1825 - 1893)与约翰·休林斯·杰克逊(1835 - 1911):19世纪法国和英国的神经病学。
J Med Biogr. 2009 Nov;17(4):210-3. doi: 10.1258/jmb.2009.009039.
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Sir Francis Walshe, MD FRS (1885-1973).弗朗西斯·沃尔什爵士,医学博士,英国皇家学会会员(1885 - 1973)。
J Med Biogr. 2006 May;14(2):93-5. doi: 10.1258/j.jmb.2006.04-28.

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