患有乳糜泻的儿童对不同乙肝疫苗接种方案的反应性。
Responsiveness of children with celiac disease to different hepatitis B vaccination protocols.
作者信息
Balamtekın Necati, Uslu Nuray, Baysoy Gökhan, Saltik-Temızel Inci, Demır Hülya, Yüce Aysel
机构信息
Department of Pediatrics, Section of Gastroenterology, Hacettepe University School of Medicine, Ankara.
出版信息
Turk J Gastroenterol. 2011 Feb;22(1):27-31. doi: 10.4318/tjg.2011.0152.
BACKGROUND/AIMS: We aimed to compare the response rates to hepatitis B virus vaccination in the first year of life, using two different immunization protocols, in children with celiac disease.
METHODS
Study Group 1 included patients with celiac disease who received 10 μg of hepatitis B vaccine intramuscularly at birth (0), 2 and 9-12 months of life. Group 2 included those who received hepatitis B vaccine at 0, 1 and 6 months of life. Healthy children were divided into two control groups according to the above schedules.
RESULTS
The total study group included 64 patients and 49 healthy controls. Celiac patients were found to have lower response rates with respect to controls (78.1% vs. 95.9%, respectively). The difference in response rates in the two patient groups was not statistically significant.
CONCLUSIONS
The response rates of celiac patients to the two different hepatitis B vaccination schedules showed no statistically significant difference.
背景/目的：我们旨在比较乳糜泻患儿在出生后第一年采用两种不同免疫方案接种乙型肝炎疫苗的应答率。
方法
研究组1包括在出生时（0月）、2个月以及9 - 12个月时肌肉注射10μg乙型肝炎疫苗的乳糜泻患者。研究组2包括在0月、1个月以及6个月时接种乙型肝炎疫苗的患者。健康儿童根据上述方案分为两个对照组。
结果
整个研究组包括64例患者和49例健康对照。发现乳糜泻患者相对于对照组应答率较低（分别为78.1%和95.9%）。两组患者的应答率差异无统计学意义。
结论
乳糜泻患者对两种不同乙型肝炎疫苗接种方案的应答率无统计学显著差异。
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