Dovern A, Fink G R, Weiss P H
Institut für Neurowissenschaften und Medizin (INM-3), Forschungszentrum Jülich.
Fortschr Neurol Psychiatr. 2011 Jun;79(6):345-57. doi: 10.1055/s-0029-1246097. Epub 2011 Apr 8.
Apraxia is a disorder of higher motor cognition. Deficits in imitating abstract and symbolic gestures as well as deficits in appropriate tool use are common apraxic symptoms which, importantly, cannot be explained by primary sensorimotor deficits alone. In spite of the relevance of apraxia for neurorehabilitation and the individual stroke patient's prognosis, apraxia is to date still too rarely diagnosed and treated. In this review the currently published assessments for the diagnosis of apraxia are evaluated. Based on this, an apraxia screening instrument as well as a diagnostic test for clinical use are recommended. In addition, different published approaches to the therapy for apraxia are described. Although current evidence is scarce, the gesture training suggested by Smania and co-workers can be recommended as a therapy for apraxia, because its effects were shown to extend to activities of daily living and to persist for at least two months after completion of the training. This review aims at directing the clinician's attention to the importance of apraxia. Moreover, it provides the interested reader with instruments for a reliable diagnosis and effective treatment of apraxia. These are also important prerequisites for further research into the neurobiological mechanisms underlying apraxia and the development of new therapy strategies leading to an evidence-based effective treatment of apraxia.
失用症是一种高级运动认知障碍。模仿抽象和象征性手势的缺陷以及在适当使用工具方面的缺陷是常见的失用症状,重要的是,这些症状不能仅用原发性感觉运动缺陷来解释。尽管失用症与神经康复以及个体中风患者的预后相关,但迄今为止,失用症的诊断和治疗仍然很少。在这篇综述中,对目前已发表的失用症诊断评估方法进行了评价。在此基础上,推荐了一种失用症筛查工具以及一种临床诊断测试。此外,还描述了已发表的不同失用症治疗方法。尽管目前证据稀少,但Smania及其同事提出的手势训练可推荐作为失用症的一种治疗方法,因为其效果已显示可扩展到日常生活活动,并且在训练完成后至少持续两个月。这篇综述旨在引导临床医生关注失用症的重要性。此外,它为感兴趣的读者提供了可靠诊断和有效治疗失用症的工具。这些也是进一步研究失用症潜在神经生物学机制以及开发新的治疗策略以实现基于证据的失用症有效治疗的重要前提。