Department of Pharmacology & Toxicology, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria.
J Med Food. 2011 Jun;14(6):640-4. doi: 10.1089/jmf.2010.0117. Epub 2011 Apr 11.
Decoctions of Hibiscus sabdariffa L. (Family Malvaceae) are very popular for the preparation of homemade refreshing drinks and are also used medicinally for a variety of ailments. Particularly remarkable are the various scientific reports supporting diuretic and antihypertensive potentials. It is therefore not unusual for patients who are on orthodox antihypertensive medications to use medicinal H. sabdariffa drinks concomitantly without regard to the possibility of herb-drug interactions. This possibility necessitated this study in which the pharmacokinetic and pharmacodynamic interactions of H. sabdariffa extract (HSE) and hydrochlorothiazide (HCT), a commonly prescribed diuretic drug, were examined. The effects of concomitant administration of HSE on urine volume, urine pH, and urinary concentrations of sodium, bicarbonate, and chloride ions, as well as on the pharmacokinetic parameters of HCT, were determined in experimental rats and rabbits. Co-administration of HSE with HCT caused a significant increase in the volume of urine excreted and resulted in a decrease in the pH of urine and the concentrations of sodium, bicarbonate, and chloride ions. Co-administration of HSE (20-40 mg/kg) with HCT (10 mg/kg) increased and prolonged the plasma concentration, the mean area under the concentration-time curve, and the volume of distribution of HCT achieved over the 24-hour sampling period. The plasma clearance and the elimination rate constant of HCT decreased with increasing dose of HSE co-administered with the HCT. The results of this study reveal a possible herb-drug interaction involving HCT and HSE, used as an ingredient in medicinal or refreshing drinks in many countries.
洛神花（锦葵科）的煎剂非常受欢迎，可用于制作自制清爽饮料，也可药用治疗各种疾病。特别值得注意的是，有大量科学报告支持其具有利尿和降压潜力。因此，许多国家将洛神花作为药用或清爽饮料的成分，同时使用传统降压药物和药用洛神花饮料的患者并不少见，而人们往往没有考虑到草药-药物相互作用的可能性。正是出于这种可能性，才进行了这项研究，以检验洛神花提取物（HSE）和氢氯噻嗪（HCT）——一种常用的利尿药物——的药代动力学和药效动力学相互作用。在实验大鼠和兔子中，测定了同时给予 HSE 对尿量、尿 pH 值以及尿中钠离子、碳酸氢根离子和氯离子浓度的影响，以及对 HCT 的药代动力学参数的影响。HSE 与 HCT 同时给药可显著增加尿量，并降低尿液 pH 值以及钠离子、碳酸氢根离子和氯离子浓度。HSE（20-40mg/kg）与 HCT（10mg/kg）同时给药可增加并延长 HCT 的血浆浓度、浓度-时间曲线下面积和分布容积，在 24 小时采样期间达到。随着与 HCT 同时给予的 HSE 剂量增加，HCT 的血浆清除率和消除率常数降低。本研究结果揭示了 HCT 和 HSE 之间可能存在草药-药物相互作用，HCT 和 HSE 作为许多国家药用或清爽饮料的成分。
