Liu Jer-Yuh, Chen Chang-Che, Wang Wen-Hong, Hsu Jeng-Dong, Yang Mon-Yuan, Wang Chau-Jong
Institute of Biochemistry and Biotechnology, College of Medicine, Chung Shan Medical University, Taichung, Taiwan.
Food Chem Toxicol. 2006 Mar;44(3):336-43. doi: 10.1016/j.fct.2005.08.003. Epub 2005 Sep 19.
Dried flower Hibiscus sabdariffa L. (HSE) extracts, a local soft drink material and medicinal herb, were studied for their protective effects against liver fibrosis induced using carbon tetrachloride (CCl(4)) in rats. Male Wistar rats were administered CCl(4) by intraperitoneal injection for 7weeks and received a normal diet or normal diet with various HSE doses (1-5%) for 9weeks. HSE significantly reduced the liver damage including steatosis and fibrosis in a dose dependent manner. Moreover, HSE significantly decreased the elevation in plasma aspartate aminotransferase (AST) and alanine aminotransferase (ALT). It also restored the decrease in glutathione content and inhibited the formation of lipid peroxidative products during CCl(4) treatment. In the primary culture, HSE also significantly inhibited the activation of the hepatic stellate cells. These results suggested that HSE may protect the liver against CCl(4)-induced fibrosis. This protective effect appears due to HSEs antioxidant properties.
木槿花（Hibiscus sabdariffa L.，HSE）提取物是一种当地的软饮料原料和草药，本研究旨在探讨其对四氯化碳（CCl₄）诱导的大鼠肝纤维化的保护作用。雄性Wistar大鼠腹腔注射CCl₄ 7周，并给予正常饮食或添加不同剂量（1-5%）HSE的正常饮食9周。HSE以剂量依赖性方式显著减轻了包括脂肪变性和纤维化在内的肝损伤。此外，HSE显著降低了血浆天冬氨酸转氨酶（AST）和丙氨酸转氨酶（ALT）的升高。它还恢复了谷胱甘肽含量的降低，并抑制了CCl₄处理期间脂质过氧化产物的形成。在原代培养中，HSE也显著抑制了肝星状细胞的活化。这些结果表明，HSE可能对CCl₄诱导的肝纤维化具有保护作用。这种保护作用似乎归因于HSE的抗氧化特性。
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