Department of Dermato-allergology, National Allergy Research Centre, Gentofte Hospital, University of Copenhagen, 2900 Hellerup, Denmark.
Contact Dermatitis. 2011 May;64(5):258-64. doi: 10.1111/j.1600-0536.2011.01889.x.
Fragrances frequently cause contact allergy, and cosmetic products are the main causes of fragrance contact allergy. As the various products have distinctive forms of application and composition of ingredients, some product groups are potentially more likely to play a part in allergic reactions than others.
To determine which cosmetic product groups cause fragrance allergy among Danish eczema patients.
This was a retrospective study based on data collected by members of the Danish Contact Dermatitis Group. Participants (N = 17,716) were consecutively patch tested with fragrance markers from the European baseline series (2005-2009).
Of the participants, 10.1% had fragrance allergy, of which 42.1% was caused by a cosmetic product: deodorants accounted for 25%, and scented lotions 24.4%. A sex difference was apparent, as deodorants were significantly more likely to be listed as the cause of fragrance allergy in men (odds ratio 2.2) than in women. Correlation was observed between deodorants listed as the cause of allergy and allergy detected with fragrance mix II (FM II) and hydroxyisohexyl 3-cyclohexene carboxaldehyde.
Deodorants were the leading causes of fragrance allergy, especially among men. Seemingly, deodorants have an 'unhealthy' composition of the fragrance chemicals present in FM II.
香料经常会引起接触过敏,而化妆品是引起香料接触过敏的主要原因。由于各种产品具有不同的应用形式和成分组成,某些产品类别比其他产品类别更有可能引发过敏反应。
确定丹麦湿疹患者中哪些化妆品类别会引起香料过敏。
这是一项基于丹麦接触性皮炎组成员收集的数据的回顾性研究。参与者(N=17716)连续接受了来自欧洲基础系列的香料标记物(2005-2009 年)的斑贴试验。
参与者中有 10.1%存在香料过敏,其中 42.1%是由化妆品引起的:除臭剂占 25%,香薰乳液占 24.4%。男女之间存在明显的性别差异,因为与女性相比,男性更有可能将除臭剂列为香料过敏的原因(优势比 2.2)。在被列为过敏原因的除臭剂和与香料混合物 II(FM II)和羟基异己基 3-环己烯甲醛检测到的过敏之间存在相关性。
除臭剂是香料过敏的主要原因,尤其是在男性中。显然,除臭剂中含有 FM II 中存在的香料化学物质的“不健康”成分。