Na+/H+ 交换器 3 在男性生殖道酸化和男性生育力中的作用。

Role of Na+ /H+ exchanger 3 in the acidification of the male reproductive tract and male fertility.

Departments of Physiology Biotechnology, Faculty of Science, Mahidol University, Bangkok, Thailand.

Clin Exp Pharmacol Physiol. 2011 Jul;38(7):403-9. doi: 10.1111/j.1440-1681.2011.05525.x.

Abstract

Male fertility is a complex process that is dependent on sex hormones and the normal function of the reproductive organs. Defects of these organs result in abnormal sperm production and function, which, in turn, lead to infertility. 2. Spermatozoa released from the testis are unable to move and fertilize with eggs. These features, known as sperm maturation, are acquired during their transit through the epididymis. 3. Among several processes that take place in the epididymis, absorption and acidification of the luminal fluid are essential for sperm maturation, sperm storage and fertility. Currently, the mechanism by which acidification occurs in the epididymis is still not fully understood. 4. The epididymis is fully equipped with the proteins required for acid/base transport, such as Na(+) /H(+) exchanger 3 (NHE3, SLC9A3), vacuolar-type adenosine triphosphatase (V-ATPase) and various isoforms of enzyme carbonic anhydrase (CA). 5. Most studies, so far, have focused on the role of V-ATPase on H(+) secretion and acidification of the epididymis. The involvement of NHE3 in creating the acidic environment of the epididymal spermatozoa receives little attention. 6. This review presents evidence for and discusses the role of NHE3 in the acidification of the male reproductive tract and its requirement for male fertility.

摘要

男性生育能力是一个复杂的过程，依赖于性激素和生殖器官的正常功能。这些器官的缺陷会导致精子产生和功能异常，进而导致不育。
从睾丸释放的精子无法移动，无法与卵子受精。这些特征，即精子成熟，是在它们通过附睾转运过程中获得的。
在附睾中发生的几个过程中，管腔液的吸收和酸化对于精子成熟、精子储存和生育能力至关重要。目前，附睾酸化发生的机制仍不完全清楚。
附睾配备了进行酸碱转运所需的蛋白质，例如 Na(+) /H(+) 交换器 3（NHE3，SLC9A3）、液泡型三磷酸腺苷酶（V-ATPase）和各种同工型碳酸酐酶（CA）。
迄今为止，大多数研究都集中在 V-ATPase 在附睾 H(+) 分泌和酸化中的作用上。NHE3 在创造附睾精子的酸性环境中的作用很少受到关注。
本综述提供了证据，并讨论了 NHE3 在男性生殖道酸化及其对男性生育能力的要求中的作用。