Department of Surgery Department of Internal Medicine Research Institute for Health Sciences, Chiang Mai University, Thailand.
Diabet Med. 2011 May;28(5):608-11. doi: 10.1111/j.1464-5491.2011.03262.x.
Studies within the Caucasian population with diabetes showed an increased mortality in patients with diabetic foot ulcers. However, there were no such studies based on Asian populations. We therefore designed our study on the association of foot ulcer with mortality within the Asian population.
Ninety-seven Asian individuals with diabetes who had previously participated in the 'Multidisciplinary Diabetic Foot Protocol' between 2005 and 2007 at our centre were followed up in 2010 to ascertain their mortality rate. Cox proportional-hazard regression analyses were used to estimate hazard ratios.
Forty-seven patients had a history of foot ulcer (group 1), while 50 had none (group 2). The mean follow-up was 43.74 months. Twenty-one patients died during this period (21.65%). The mortality rates in group 1 and group 2 were 15 (31.92%) and six (12.00%), respectively. Patients with a history of foot ulcer had higher mortality rates than those without (hazard ratio 3.51, 95% CI 1.03-11.96, P = 0.04).
Our study showed that history of foot ulcer increased mortality. This association appeared to be stronger in younger Asian patients than those in the Caucasian populations.
在高加索人群中进行的糖尿病研究表明，糖尿病足溃疡患者的死亡率增加。然而，基于亚洲人群的此类研究尚未进行。因此，我们设计了这项研究，以探讨亚洲人群中足部溃疡与死亡率之间的关系。
我们对 2005 年至 2007 年期间在我们中心参加过“多学科糖尿病足治疗方案”的 97 名亚洲糖尿病患者进行了随访，以确定他们的死亡率。采用 Cox 比例风险回归分析来估计风险比。
47 名患者有足部溃疡史（第 1 组），50 名患者无足部溃疡史（第 2 组）。平均随访时间为 43.74 个月。在此期间，21 名患者死亡（21.65%）。第 1 组和第 2 组的死亡率分别为 15（31.92%）和 6（12.00%）。有足部溃疡史的患者死亡率高于无足部溃疡史的患者（风险比 3.51，95%CI 1.03-11.96，P=0.04）。
我们的研究表明，足部溃疡史增加了死亡率。这种关联在年轻的亚洲患者中似乎比在高加索人群中更强。
