脐血干细胞/祖细胞的生物学研究进展。
Insights into the biology of cord blood stem/progenitor cells.
机构信息
Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, USA.
出版信息
Cell Prolif. 2011 Apr;44 Suppl 1(Suppl 1):55-9. doi: 10.1111/j.1365-2184.2010.00728.x.
OBJECTIVES
To review information on cord blood banking and transplantation with respect to the author's studies, and in context of this field of investigation.
RESULTS
Cord blood transplantation has been successfully used to treat a number of malignant and non-malignant disorders. However, this technique is still associated with limited numbers of cells for transplantation, and with delayed engraftment of neutrophils and platelets. The field of cord blood transplantation will benefit from enhanced and mechanistically based information on haematopoietic stem cell function and potential means to enhance its effectiveness are reviewed. This includes notions concerning possibility of retrieving more cells from the placenta and cord blood, to expand haematopoietic stem cells ex vivo and to increase efficiency of homing and engraftment of these cells. Also discussed are cryopreservation and long-term storage of cord blood haematopoietic and progenitor cells, and new laboratory findings and animal studies for non-haematopoietic uses of cord blood.
目的
回顾作者研究中有关脐血库和移植的信息，并结合该领域的研究进展。
结果
脐血移植已成功用于治疗多种恶性和非恶性疾病。然而，该技术仍与可用于移植的细胞数量有限以及中性粒细胞和血小板植入延迟有关。通过增强和基于机制的造血干细胞功能信息，并回顾增强其效果的潜在方法，脐血移植领域将从中受益。这包括从胎盘和脐血中获取更多细胞、体外扩增造血干细胞以及提高这些细胞归巢和植入效率的可能性等概念。此外，还讨论了脐血造血和祖细胞的冷冻保存和长期储存，以及用于非造血用途的新的实验室发现和动物研究。
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