脐带血移植：尾声。
Umbilical cord transplantation: epilogue.
机构信息
Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202-5181, USA.
出版信息
Semin Hematol. 2010 Jan;47(1):97-103. doi: 10.1053/j.seminhematol.2009.10.002.
Abstract
The field of cord blood transplantation has come a long way since the first transplant more than 20 years ago. Advancements in the field will require continuing efforts to better understand hematopoietic stem and progenitor cell function and engraftment. Cautious optimism is inherent in the potential relevance and applicability of nonhematopoietic stem and progenitor cell types found in cord blood, and induced pluripotent stem cells generated from cord blood cells. Rigorous investigations and close interactions between scientific and clinical investigators are required to translate human in vitro and animal in vivo findings into clinical utility.
摘要
自 20 多年前首例脐带血移植以来，脐带血移植领域已经取得了长足的发展。该领域的进展需要不断努力，以更好地了解造血干细胞和祖细胞的功能和植入。在脐带血中发现的非造血干细胞和祖细胞类型，以及从脐带血细胞中产生的诱导多能干细胞，具有潜在的相关性和适用性，这是谨慎的乐观。需要进行严格的研究，并在科学和临床研究人员之间进行密切互动，将人体体外和动物体内的发现转化为临床应用。
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