Department of Dermatology, Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Korea.
Dermatol Surg. 2011 Apr;37(4):463-8. doi: 10.1111/j.1524-4725.2011.01916.x.
Fractional carbon dioxide laser resurfacing (FxCR) has shown considerable efficacy in reducing wrinkles, although complications such as scarring and prolonged erythema are more common and down-time is longer than with nonablative laser treatment. Platelet-rich plasma (PRP), a high concentration of platelets in a small volume of plasma, is known to enhance tissue healing.
To evaluate the benefits of PRP in the wound healing process after FxCR.
Twenty-five subjects were treated with FxCR on the bilateral inner arms. PRP was prepared from 10 mL of whole blood and applied on a randomly allocated side, with normal saline being used as the contralateral control. Transepidermal water loss (TEWL) and skin color were measured on both sides. Skin biopsies were also taken from five subjects on day 28.
Significantly faster recovery of TEWL was seen on the PRP-treated side. The erythema index and melanin index on the PRP-treated side were lower than on the control side. Biopsy specimens from the PRP-treated side showed thicker collagen bundles than those from the control side.
Application of autologous PRP is an effective method for enhancing wound healing and reducing transient adverse effects after FxCR treatment.
分 子 氧 化 二 碳 激 光 焕 肤（FxCR）在减少皱纹方面显示出相当大的疗效，尽管并发症如瘢痕和延长的红斑比非剥脱性激光治疗更常见且恢复期更长。富血小板血浆（PRP）是一种高浓度的血小板在少量血浆中，已知能促进组织愈合。
评估 PRP 在 FxCR 后伤口愈合过程中的益处。
25 名受试者在内臂两侧接受 FxCR 治疗。PRP 从 10 毫升全血中制备，并随机分配到一侧，另一侧用生理盐水作为对照。测量两侧的经皮水分丢失（TEWL）和皮肤颜色。还从 5 名受试者的第 28 天取皮肤活检。
在 PRP 治疗侧，TEWL 更快恢复。PRP 治疗侧的红斑指数和黑色素指数均低于对照组。PRP 治疗侧的活检标本显示出比对照组更厚的胶原束。
应用自体 PRP 是一种有效方法，可增强 FxCR 治疗后伤口愈合和减少短暂不良反应。
