Maged Ahmed M, Mohsen Reham A, Salah Noha, Ragab Wael S
Department of Obstetrics and Gynecology, Kasr Al-Ainy Hospital, Cairo University, Cairo, Egypt.
Department of Obstetrics and Gynecology, Faculty of Medicine, Fayoum University, Fayoum, Egypt.
BMC Pregnancy Childbirth. 2024 Jan 27;24(1):85. doi: 10.1186/s12884-024-06251-2.
To assess the value of intraovarian PRP in women with low ovarian reserve.
Screening of databases from inception to January 2023 using the keywords related to "Platelet-rich plasma" AND "poor ovarian reserve" OR "ovarian failure".
Fourteen studies (1632 participants) were included, 10 included women with POR, 1 included women with POI and 3 included both POR and POI women.
Extracted data included study settings, design, sample size, population characteristics, volume, timing and preparation of PRP administration, and outcome parameters.
AMH level was evaluated in 11 studies (2099 women). The mean difference (MD) was 0.09 with 95% CI of - 0.06, 0.24 (P = 0.25). Antral follicular count level was assessed in 6 studies (1399 women). The MD was 1.73 with 95% CI of 0.81, 2.66 (P < 0.001). The number of oocytes retrieved was evaluated in 7 studies (1413 women). The MD was 1.21 with 95% CI of 0.48, 1.94 (P = 0.001).
This systematic review found a significant improvement of AFC, the number of retrieved oocytes, the number of cleavage embryos and the cancellation rate in women with POR.
Registration number CRD42022365682.
评估卵巢内注射富血小板血浆（PRP）对卵巢储备功能低下女性的价值。
从数据库建库至2023年1月，使用与“富血小板血浆”和“卵巢储备功能不良”或“卵巢功能衰竭”相关的关键词进行筛查。
纳入14项研究（1632名参与者），其中10项纳入了卵巢储备功能低下的女性，1项纳入了原发性卵巢功能不全的女性，3项同时纳入了卵巢储备功能低下和原发性卵巢功能不全的女性。
提取的数据包括研究背景、设计、样本量、人群特征、PRP注射的体积、时间和制备方法以及结局参数。
11项研究（2099名女性）评估了抗苗勒管激素（AMH）水平。平均差异（MD）为0.09，95%置信区间为-0.06, 0.24（P = 0.25）。6项研究（1399名女性）评估了窦卵泡计数水平。MD为1.73，95%置信区间为0.81, 2.66（P < 0.001）。7项研究（1413名女性）评估了获卵数。MD为1.21，95%置信区间为0.48, 1.94（P = 0.001）。
本系统评价发现，卵巢储备功能低下女性的窦卵泡计数、获卵数、卵裂期胚胎数及取消周期率有显著改善。
注册号CRD42022365682。
