Glynn Liam, Fahey Tom
National University of Ireland, Galway, Ireland.
BMJ Clin Evid. 2011 Apr 11;2011:0220.
Adherence to medication is generally defined as the extent to which people take medications as prescribed by their healthcare providers. It can be assessed in many ways (e.g., by self-reporting, pill counting, direct observation, electronic monitoring, or by pharmacy records). This review reports effects of intervention on adherence to cardiovascular medications however adherence has been measured.
We conducted a systematic review and aimed to answer the following clinical question: What are the effects of interventions to improve adherence to long-term medication for cardiovascular disease in adults? We searched: Medline, Embase, The Cochrane Library, and other important databases up to April 2010 (Clinical Evidence reviews are updated periodically; please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA).
We found 39 systematic reviews, RCTs, or observational studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions.
In this systematic review we present information relating to the effectiveness and safety of the following interventions: patient health education, prescriber education, prompting mechanisms, reminder packaging (calendar [blister] packs, multi-dose pill boxes), and simplified dosing.
服药依从性通常定义为人们按照医疗保健提供者的处方服药的程度。它可以通过多种方式进行评估（例如，通过自我报告、清点药片、直接观察、电子监测或药房记录）。本综述报告了干预措施对心血管药物服药依从性的影响，无论依从性是如何测量的。
我们进行了一项系统综述，旨在回答以下临床问题：干预措施对提高成年人心血管疾病长期用药依从性有何影响？我们检索了：截至2010年4月的Medline、Embase、Cochrane图书馆及其他重要数据库（临床证据综述会定期更新；请查看我们的网站获取本综述的最新版本）。我们纳入了来自美国食品药品监督管理局（FDA）和英国药品及医疗保健产品监管局（MHRA）等相关组织的危害警示。
我们找到了39项符合我们纳入标准的系统综述、随机对照试验或观察性研究。我们对干预措施证据的质量进行了GRADE评估。
在本系统综述中，我们提供了与以下干预措施的有效性和安全性相关的信息：患者健康教育、开处方者教育、提示机制、提醒包装（日历[泡罩]包装、多剂量药盒）和简化给药方案。
