中枢神经系统疾病相关失眠——发生与处理。

Insomnia in central neurologic diseases--occurrence and management.

机构信息

Hephata Klinik, Schwalmstadt-Treysa, Germany.

出版信息

Sleep Med Rev. 2011 Dec;15(6):369-78. doi: 10.1016/j.smrv.2011.01.005. Epub 2011 Apr 9.

Abstract

The objective of this review is to highlight the impact of insomnia in central neurological disorders by providing information on its prevalence and give recommendations for diagnosis and treatment. Insomnia in neurological disorders is a frequent, but underestimated symptom. Its occurrence may be a direct consequence of the disease itself or may be secondary to pain, depression, other sleep disorders or the effects of medications. Insomnia can have a significant impact on the patient's cognitive and physical function and may be associated with psychological distress and depression. Diagnosis of insomnia is primarily based on medical history and validated questionnaires. Actigraphy is a helpful diagnostic tool for assessing the circadian sleep-wake rhythm. For differential diagnosis and to measure the duration of sleep full polysomnography may be recommended. Prior to initiating treatment the cause of insomnia must be clearly identified. First line treatment aims at the underlying neurologic disease. The few high quality treatment studies show that short term treatment with hypnotics may be recommended in most disorders after having ruled out high risk for adverse effects. Sedating antidepressants may be an effective treatment for insomnia in stroke and Parkinson's disease (PD) patients. Melatonin and light treatment can stabilize the sleep-wake circadian rhythm and shorten sleep latency in dementias and PD. Cognitive behavioral therapy (CBT) can be effective in treating insomnia symptoms associated with most of the central neurological diseases. The prevalence and treatment of insomnia in neurological diseases still need to be studied in larger patient groups with randomized clinical trials to a) better understand their impact and causal relationship and b) to develop and improve specific evidence-based treatment strategies.

摘要

本次综述旨在通过介绍其患病率,为神经系统疾病患者的失眠诊断和治疗提供建议,以突出失眠对中枢神经系统疾病的影响。在神经系统疾病中,失眠是一种常见但被低估的症状。它的发生可能是疾病本身的直接后果,也可能继发于疼痛、抑郁、其他睡眠障碍或药物的影响。失眠会对患者的认知和身体功能产生重大影响,并可能与心理困扰和抑郁有关。失眠的诊断主要基于病史和经过验证的问卷。活动记录仪是评估昼夜睡眠-觉醒节律的有用诊断工具。为了进行鉴别诊断和测量睡眠总时长,可能需要推荐进行全夜多导睡眠图。在开始治疗之前,必须明确失眠的原因。一线治疗旨在治疗潜在的神经系统疾病。为数不多的高质量治疗研究表明,在排除了不良反应高风险后,在大多数疾病中,短期使用催眠药可能是合理的。镇静性抗抑郁药可能是治疗中风和帕金森病(PD)患者失眠的有效方法。褪黑素和光照治疗可以稳定睡眠-觉醒昼夜节律,并缩短痴呆和 PD 患者的睡眠潜伏期。认知行为疗法(CBT)可有效治疗与大多数中枢神经系统疾病相关的失眠症状。还需要在更大的患者群体中进行随机临床试验,以研究神经系统疾病中的失眠患病率和治疗方法,以更好地了解其影响和因果关系,并制定和改进特定的基于证据的治疗策略。

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