Brachet P, de Leval L, Chantrain G, Loeb I, Saussez S
Service d'oto-rhino-laryngologie et de chirurgie cervico-faciale, CHU Saint-Pierre, Brussels, Belgium.
Rev Stomatol Chir Maxillofac. 2011 Jun;112(3):180-2. doi: 10.1016/j.stomax.2011.01.011. Epub 2011 Apr 8.
Non-Hodgkin lymphomas are common cancers that can develop in the upper aero-digestive tract. We describe a case of a large B-cell palatine lymphoma with spontaneous clinical regression.
A 58-year-old female patient presented with a sub-mucosal lesion of the hard palate. CT scan and magnetic resonance imaging revealed a lesion invading the right posterior palatine canal. At the second consultation, 15 days after performing the biopsy, the lesion had disappeared. PET scan proved the absence of lesion. Lymph node biopsy supported the diagnosis of large B-cell lymphoma.
Large B-cell lymphoma of the hard palate is a rare disease. Only 27 cases have been described in the international literature. The anatomopathological analysis is often difficult to perform. The final diagnosis is often made by immunochemistry. The usual treatment is R-CHOP chemotherapy (cyclophosphamide, adriamycin, vincristine, prednisone combined to rituximab) with a 5-year survival rate at 55%.
非霍奇金淋巴瘤是常见的癌症，可发生于上呼吸消化道。我们描述一例大型B细胞腭部淋巴瘤自发临床消退的病例。
一名58岁女性患者，硬腭出现黏膜下病变。CT扫描和磁共振成像显示病变侵犯右侧腭后管。活检后15天进行第二次会诊时，病变已消失。PET扫描证实无病变。淋巴结活检支持大型B细胞淋巴瘤的诊断。
硬腭大型B细胞淋巴瘤是一种罕见疾病。国际文献中仅描述了27例。解剖病理学分析通常难以进行。最终诊断常通过免疫化学作出。常用治疗方法是R-CHOP化疗（环磷酰胺、阿霉素、长春新碱、泼尼松联合利妥昔单抗），5年生存率为55%。
