Division of Microbiology, Department of Health Sciences, Faculty of Experimental Sciences, University of Jaén, Jaén, Spain.
Nutrition. 2011 Oct;27(10):1053-60. doi: 10.1016/j.nut.2010.11.011. Epub 2011 Apr 9.
The ω-3 polyunsaturated fatty acids can suppress immune system functions. This property may cause adverse effects by impairing host resistance to infection. The present study focused on estimating the impact of different dietary lipids on the immune system of mice after a secondary infection with Listeria monocytogenes.
BALB/c mice were divided into five dietary groups of olive oil, fish oil, sunflower oil, high-oleic sunflower oil, or low fat that was administered for 8 wk. The mice were immunized with 10(3) colony-forming units. Thirty-eight days later, each mouse was challenged with 10(4) colony-forming units. Mice survival and bacterial clearance from livers and spleens were determined. In addition, cytokine, chemokine, and adhesion molecule productions were quantified from the sera.
Survival percentage in mice fed a fish oil diet was 100% and bacterial numbers from spleen were decreased at 72 h. Interleukin-12, intercellular adhesion molecule-1, and vascular cell adhesion molecule-1 productions were decreased. Levels of tumor necrosis factor-α and interferon-γ were increased, whereas macrophage inflammatory protein-1α (MIP-1α) production was unaltered.
Immune defense in mice fed a fish oil diet was improved after secondary exposure, acquiring an adequate resistance. This result could be attributable to an increase of a T-helper type 1 response.
ω-3 多不饱和脂肪酸可抑制免疫系统功能。这种特性可能会通过损害宿主对感染的抵抗力而产生不良反应。本研究旨在评估不同膳食脂质对李斯特菌二次感染后小鼠免疫系统的影响。
BALB/c 小鼠分为橄榄油、鱼油、葵花籽油、高油酸葵花籽油和低脂 5 组膳食组，分别喂食 8 周。用 10(3)个菌落形成单位对小鼠进行免疫接种。38 天后，每只小鼠接受 10(4)个菌落形成单位的攻击。测定小鼠的存活率和肝脏及脾脏的细菌清除率。此外，还从血清中定量测定细胞因子、趋化因子和黏附分子的产生。
喂食鱼油饮食的小鼠存活率为 100%，且 72 小时时脾脏中的细菌数量减少。白细胞介素-12、细胞间黏附分子-1 和血管细胞黏附分子-1 的产生减少。肿瘤坏死因子-α和干扰素-γ水平升高，而巨噬细胞炎性蛋白-1α（MIP-1α）的产生不变。
二次暴露后，喂食鱼油饮食的小鼠的免疫防御能力得到改善，获得了足够的抵抗力。这一结果可能归因于辅助性 T 细胞 1 型反应的增加。
