Radiation Medicine Program, Princess Margaret Hospital, Toronto, ON, Canada.
Clin Oncol (R Coll Radiol). 2011 Sep;23(7):476-81. doi: 10.1016/j.clon.2011.01.001. Epub 2011 Apr 9.
To evaluate the efficacy of a palliative three fraction radiation regimen delivered on days 0, 7 and 21 (0-7-21 regimen) for advanced stage gynaecological cancer patients.
Fifty-one patients with advanced gynaecological cancer who were treated with the 0-7-21 regimen between 1998 and 2008 were identified. The median follow-up period was 1.4 months (range 0.2-33.4). Treatment completion data, symptomatic response, toxicity and survival were retrospectively analysed.
Forty-eight patients received at least two of the three planned fractions. Complete and partial responses of vaginal bleeding were seen in 92% of 26 evaluable patients. Complete and partial responses of pain were seen in 76% of 25 evaluable patients. Eighteen of the 33 evaluable patients experienced grade 1/2 acute toxicity. No patients experienced grade 3/4 toxicity. Grade 1/2 and grade 3 late toxicity occurred in four and one of 12 evaluable patients, respectively. Grade 5 toxicity was assigned in two patients. It was uncertain whether these deaths were radiation related or due to tumour progression. Eleven patients survived longer than 12 months.
The 0-7-21 regimen provided effective and rapid symptomatic relief with acceptable toxicity, and offered the advantage of convenience for most patients. It offers an alternate treatment option for carefully selected patients with incurable gynaecological malignancies.
评估在第 0、7 和 21 天（0-7-21 方案）给予姑息性三分割放疗治疗晚期妇科癌症患者的疗效。
1998 年至 2008 年间，共确定了 51 例接受 0-7-21 方案治疗的晚期妇科癌症患者。中位随访时间为 1.4 个月（范围 0.2-33.4）。回顾性分析了治疗完成情况、症状缓解、毒性和生存情况。
48 例患者至少接受了计划中的三分之二的放疗。在 26 例可评估的患者中，92%的患者阴道出血完全或部分缓解。在 25 例可评估的患者中，76%的患者疼痛完全或部分缓解。18 例 33 例可评估患者出现 1/2 级急性毒性。无 3/4 级毒性。在 12 例可评估患者中，分别有 4 例和 1 例出现 1/2 级和 3 级迟发性毒性。2 例患者出现 5 级毒性。这些死亡是与放疗相关还是由于肿瘤进展尚不确定。11 例患者的生存期超过 12 个月。
0-7-21 方案提供了有效且快速的症状缓解，毒性可接受，对大多数患者来说具有方便的优势。对于精心选择的无法治愈的妇科恶性肿瘤患者，它提供了一种替代治疗选择。
