前列环素：肾上腺类固醇生成的强效刺激剂。

Prostacyclin: a potent stimulator of adrenal steroidogenesis.

作者信息

Ellis E F, Shen J C, Schrey M P, Carchman R A, Rubin R P

出版信息

Prostaglandins. 1978 Oct;16(4):483-90. doi: 10.1016/0090-6980(78)90178-8.

Abstract

The relative potencies of various prostaglandins were investigated in trypsin-dispersed cat adrenocortical cells. Prostacyclin proved to be the most potent steroidogenic prostaglandin, being 100-1000 times more potent than PGE2. This stimulant effect of prostacyclin was only partially dependent upon the presence of extracellular calcium and was associated with increased levels of cyclic AMP. These data suggest a possible role for prostacyclin in corticosteroidogenesis.

摘要

在胰蛋白酶分散的猫肾上腺皮质细胞中研究了各种前列腺素的相对效力。结果表明，前列环素是最有效的促类固醇生成的前列腺素，其效力比前列腺素E2强100至1000倍。前列环素的这种刺激作用仅部分依赖于细胞外钙的存在，并且与环磷酸腺苷水平的升高有关。这些数据表明前列环素在皮质类固醇生成中可能发挥作用。