尼古丁对猫肾上腺皮质细胞类固醇生成的刺激作用。
Nicotine-induced stimulation of steroidogenesis in adrenocortical cells of the cat.
作者信息
Rubin R P, Warner W
出版信息
Br J Pharmacol. 1975 Mar;53(3):357-62. doi: 10.1111/j.1476-5381.1975.tb07371.x.
Abstract
- The effect of nicotine on steroid production and release from trypsin-dispersed cat adrenocortical cells was investigated. 2. Nicotine, like adrenocorticotrophin (ACTH), elicited a dose-dependent increase in steroidogenesis, which depended upon the presence of calcium in the medium. 3. Augmented steroid production evoked by submaximal concentrations of ACTH monobutyryl cyclic adenosine 3',5'-monophosphate (AMP), or prostaglandin E2 was further enhanced by steroidogenic concentrations of nicotine. 4. These results are discussed in relation to the possible mode of action of nicotine on cortical cells and to the potential consequences of smoking during stress.
摘要
- 研究了尼古丁对胰蛋白酶分散的猫肾上腺皮质细胞甾体生成和释放的影响。2. 尼古丁与促肾上腺皮质激素（ACTH）一样，引起甾体生成呈剂量依赖性增加，这取决于培养基中钙的存在。3. 亚最大浓度的ACTH、单丁酰环磷腺苷（AMP）或前列腺素E2引起的甾体生成增加，在甾体生成浓度的尼古丁作用下进一步增强。4. 就尼古丁对皮质细胞可能的作用方式以及应激期间吸烟的潜在后果对这些结果进行了讨论。
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Antidiuretic Action of Nicotine.尼古丁的抗利尿作用。
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A study of the differential secretion of epinephrine and norepinephrine from the perfused cat adrenal gland.灌注猫肾上腺中肾上腺素和去甲肾上腺素分泌差异的研究。
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