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[红细胞中PGM1的酶活性]

[Enzyme activity of PGM1 in erythrocytes].

作者信息

Bajanowski T, Baumann A, Brinkmann B

机构信息

Institut für Rechtsmedizin, Westfälische Wilhelms-Universität, Münster, Bundesrepublik Deutschland.

出版信息

Z Rechtsmed. 1990;103(8):609-12. doi: 10.1007/BF01261426.

DOI:10.1007/BF01261426
PMID:2148244
Abstract

The enzyme activity of phosphoglucomutase (PGM) has been investigated in red cell haemolysates from 142 individuals and compared to the sub-type as determined by isoelectric focusing. The 10 phenotypes showed significant differences in PGM-activity which indicates that there is a correlation between the level of activity and the isolelectric point of homozygotes. No indication of silent alleles or alleles with reduced activity was found in this collective.

摘要

对142名个体的红细胞溶血产物中的磷酸葡萄糖变位酶(PGM)的酶活性进行了研究,并与通过等电聚焦确定的亚型进行了比较。这10种表型在PGM活性上表现出显著差异,这表明纯合子的活性水平与等电点之间存在相关性。在这个群体中未发现沉默等位基因或活性降低的等位基因的迹象。

相似文献

1
[Enzyme activity of PGM1 in erythrocytes].[红细胞中PGM1的酶活性]
Z Rechtsmed. 1990;103(8):609-12. doi: 10.1007/BF01261426.
2
Characterisation of the isoenzymes of phosphoglucomutase (PGM) determined by the first (PGM1) and second (PGM2) locus observed by isoelectric focusing.通过等电聚焦观察由第一(PGM1)和第二(PGM2)位点所确定的磷酸葡萄糖变位酶(PGM)同工酶的特征。
Hum Genet. 1979 Apr 5;47(3):279-90. doi: 10.1007/BF00321020.
3
Red cell PGM1 (phosphoglucomutase) phenotyping by isoelectric focussing and starch gel electrophoresis in cases of disputed paternity in the United Kingdom. An evaluation of the results obtained in 95 cases.英国亲子鉴定案例中通过等电聚焦和淀粉凝胶电泳对红细胞磷酸葡萄糖变位酶1(PGM1)进行表型分析。对95个案例所获结果的评估。
Forensic Sci Int. 1979 Mar-Apr;13(2):87-92. doi: 10.1016/0379-0738(79)90268-8.
4
[Silent allele of the PGM1 system of erythrocytic phosphoglucomutase].
Soud Lek. 1981;26(4 Suppl):60-3.
5
Genetic evidence for four common alleles at the phosphoglucomutase-1 locus (PGM1) detectable by isoelectric focusing.通过等电聚焦可检测到磷酸葡萄糖变位酶-1基因座(PGM1)上四个常见等位基因的遗传证据。
Vox Sang. 1978;34(2):97-103. doi: 10.1111/j.1423-0410.1978.tb03730.x.
6
Phosphoglucomutase (PGM1) subtypes in a Finnish population determined by isoelectric focusing in agarose gel.通过琼脂糖凝胶等电聚焦法测定芬兰人群中的磷酸葡萄糖变位酶(PGM1)亚型。
Hum Hered. 1985;35(2):95-100. doi: 10.1159/000153523.
7
PGM1 subtypes in Cantabria (middle N Spain).坎塔布里亚(西班牙中部)的PGM1亚型。
Gene Geogr. 1995 Apr;9(1):59-63.
8
Red cell phosphoglucomutase (PGM1) subtypes in Egyptians.埃及人的红细胞磷酸葡萄糖变位酶(PGM1)亚型
Forensic Sci Int. 1986 May;31(1):55-9. doi: 10.1016/0379-0738(86)90072-1.
9
Isoelectric focusing of human red cell phosphoglucomutase: the distribution of variant phenotypes in a village population from the Gambia, West Africa.人类红细胞磷酸葡萄糖变位酶的等电聚焦:西非冈比亚一个乡村人群中变异表型的分布
Hum Genet. 1978 Sep 19;43(3):307-13. doi: 10.1007/BF00278838.
10
Isoelectric focusing of red cell phosphoglucomutase (E.C.: 2.7.5.1) at the PGM1 locus in a French-Canadian population.在法裔加拿大人群中,对PGM1位点的红细胞磷酸葡萄糖变位酶(酶编号:2.7.5.1)进行等电聚焦分析。
Hum Genet. 1981;59(1):36-8. doi: 10.1007/BF00278851.

本文引用的文献

1
PHOSPHOGLUCOMUTASE POLYMORPHISM IN MAN.人类中的磷酸葡萄糖变位酶多态性
Nature. 1964 Nov 21;204:742-5. doi: 10.1038/204742a0.
2
Human phosphoglucomutase locus 1: red cell enzymatic activities associated with common isoelectric focusing phenotypes.人类磷酸葡萄糖变位酶基因座1:与常见等电聚焦表型相关的红细胞酶活性
Hum Hered. 1983;33(4):218-22. doi: 10.1159/000153381.
3
A new case of a silent allele in the PGM system.磷酸葡萄糖变位酶(PGM)系统中一个沉默等位基因的新病例。
Hum Hered. 1982;32(4):293-5.
4
[A "new" phenotype in the isoenzyme system of the human phosphoglucomutases].[人类磷酸葡萄糖变位酶同工酶系统中的一种“新”表型]
Blut. 1969 Mar;18(6):358-62. doi: 10.1007/BF01632122.
5
[A "new" phenotype in the isoenzymesystem of human phosphoglucomutases (PGM10)].
Blut. 1968;18(1):33-4. doi: 10.1007/BF01632787.
6
Red cell phosphoglucomutase polymorphism. II. Densitometric studies.红细胞磷酸葡萄糖变位酶多态性。II. 光密度测定研究。
Hum Hered. 1970;20(1):94-103. doi: 10.1159/000152299.
7
Red cell phosphoglucomutase polymorphism. I. Enzyme activity of different red cell PGM phenotypes.红细胞磷酸葡萄糖变位酶多态性。I. 不同红细胞PGM表型的酶活性
Hum Hered. 1970;20(1):86-93. doi: 10.1159/000152298.
8
Inherited partial deficiency of the PGM gene: biochemical and densitometric studies.磷酸葡萄糖变位酶基因的遗传性部分缺陷:生化与光密度测定研究
Ann Hum Genet. 1972 Mar;35(3):363-6. doi: 10.1111/j.1469-1809.1957.tb01411.x.
9
A kinetic study of the isozymes determined by the three human phosphoglucomutase loci PGM1, PGM2, and PGM3.对由人类三个磷酸葡萄糖变位酶基因座PGM1、PGM2和PGM3所决定的同工酶的动力学研究。
Eur J Biochem. 1974 Mar 1;42(2):511-7. doi: 10.1111/j.1432-1033.1974.tb03366.x.
10
[On the occurrence of the silent allele Po in 10 German families (author's transl)].
Z Rechtsmed. 1974;75(1):25-32. doi: 10.1007/BF02114958.