Franke A, Reding R, Tessmann D
Department of Surgery, University of Rostock, German Democratic Republic.
Acta Chir Scand. 1990 Oct;156(10):701-5.
A total of 107 male Wistar rats had abdominal hernias repaired (3 weeks after they had been artificially induced) by a two layer closure of the abdominal wall--the Mayo technique. The wounds of 56 rats were subjected to constant stimulation by an electric flow field. An implanted stimulation unit provided a low frequency (0.87 Hz), bipolar, symmetrical rectangular pulsed current (+/- 25 microA). A control group were given units that did not transmit current. In 39 of the 51 animals in the control group the muscle margins of the abdominal scars separated by between 1 and 5 mm. The scars of the electrostimulated animals were distinguished histologically by early formation of fibroblasts and deposition of collagen and the rapid maturation and longitudinal alignment of the collagen fibres. 46 of 56 of these scars were not separated. This technique may have a clinical application as adjuvant treatment for relapses of incisional hernias.
总共107只雄性Wistar大鼠在人工诱导腹疝3周后，采用腹壁两层缝合（梅奥技术）修复腹疝。56只大鼠的伤口受到电流场的持续刺激。一个植入式刺激装置提供低频（0.87赫兹）、双极、对称的矩形脉冲电流（±25微安）。对照组给予不传输电流的装置。对照组51只动物中有39只腹部瘢痕的肌肉边缘分离了1至5毫米。接受电刺激动物的瘢痕在组织学上表现为成纤维细胞早期形成、胶原蛋白沉积以及胶原纤维快速成熟和纵向排列。这些瘢痕中有56个中的46个没有分离。该技术可能作为切口疝复发的辅助治疗方法应用于临床。
