Song Bo-Yan, Zhu Wei-Guo
Department of Biochemistry and Molecular Biology, Health Science Center, Peking University, Beijing 100191, China.
Yi Chuan. 2011 Apr;33(4):285-92. doi: 10.3724/sp.j.1005.2011.00285.
As a significant epigenetic regulation mechanism, histone methylation plays an important role in many biological processes. In cells, there are various histone methyltransferases and histone demethylases working cooperatively to regulate the histone methylation state. Upon histone modification, effector proteins recognize modification sites specifically, and affect gene transcriptional process. This review mainly focuses on recent advances in histone methylation effector protein's function mechanism.
作为一种重要的表观遗传调控机制，组蛋白甲基化在许多生物学过程中发挥着重要作用。在细胞中，存在多种组蛋白甲基转移酶和组蛋白去甲基化酶协同作用以调节组蛋白甲基化状态。在组蛋白修饰后，效应蛋白特异性识别修饰位点，并影响基因转录过程。本综述主要关注组蛋白甲基化效应蛋白功能机制的最新进展。
