组蛋白的故事：赖氨酸甲基化，拟南芥发育中的主角。

Histone tales: lysine methylation, a protagonist in Arabidopsis development.

机构信息

Key Laboratory of South China Agricultural Plant Molecular Analysis and Genetic Improvement, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Center of Economic Botany, Core Botanical Gardens, Chinese Academy of Sciences, Guangzhou, China.

Key Laboratory of Plant Stress Biology, State Key Laboratory of Cotton Biology, School of Life Sciences, Henan University, Kaifeng, China.

出版信息

J Exp Bot. 2020 Jan 23;71(3):793-807. doi: 10.1093/jxb/erz435.

DOI:10.1093/jxb/erz435

PMID:31560751

Abstract

Histone methylation plays a fundamental role in the epigenetic regulation of gene expression driven by developmental and environmental cues in plants, including Arabidopsis. Histone methyltransferases and demethylases act as 'writers' and 'erasers' of methylation at lysine and/or arginine residues of core histones, respectively. A third group of proteins, the 'readers', recognize and interpret the methylation marks. Emerging evidence confirms the crucial roles of histone methylation in multiple biological processes throughout the plant life cycle. In this review, we summarize the regulatory mechanisms of lysine methylation, especially at histone H3 tails, and focus on the recent advances regarding the roles of lysine methylation in Arabidopsis development, from seed performance to reproductive development, and in callus formation.

摘要

组蛋白甲基化在植物中由发育和环境线索驱动的基因表达的表观遗传调控中起着基本作用，包括拟南芥。组蛋白甲基转移酶和去甲基酶分别作为赖氨酸和/或精氨酸残基核心组蛋白甲基化的“写入器”和“擦除器”。第三组蛋白质，即“读取器”，识别和解释甲基化标记。新出现的证据证实了组蛋白甲基化在植物生命周期的多个生物学过程中的关键作用。在这篇综述中，我们总结了赖氨酸甲基化的调控机制，特别是在组蛋白 H3 尾部的赖氨酸甲基化，并重点介绍了赖氨酸甲基化在拟南芥发育中的作用的最新进展，从种子性能到生殖发育，以及愈伤组织形成。