[宁夏人群中与强直性脊柱炎相关的新型淋巴毒素-α（LTA）基因的鉴定]

[Identification of a novel lymphotoxin-alpha (LTA) gene associated with ankylosing spondylitis in Ningxia population].

作者信息

Chen Jing, Zhou Lin, Huo Zheng-Hao, Zhang Yu-Hong, Yang Zhi-Hong, Yang Bao-Zhen, Huang Ci-Bo, Zhu Xiao-Quan, Yang Ze

机构信息

Institute of Geriatrics, Beijing Hospital, Ministry of Health of PR China, Beijing 100730, China.

出版信息

Yi Chuan. 2011 Apr;33(4):329-36. doi: 10.3724/sp.j.1005.2011.00329.

DOI:10.3724/sp.j.1005.2011.00329

PMID:21482522

Abstract

Lymphotoxin-alpha (LTA) gene has been reported to have a genetic association with systemic lupus erythematosus (SLE), psoriasis, and rheumatoid arthritis. However, the association of LTA with ankylosing spondylitis (AS) has not reported. By case-control study, we carried out the high density limited genome scanning to the HLA class III region about 58 kb in Ningxia population (case 300 and control 385). In this study, 33 SNPs in LTA were genotyped in Ningxia population. We analyzed these SNPs and the haplotypes covering LTA. Only the distribution of TCC haplotype which contains mutation allele of LTA rs909253 was statistically significant(P=0.0005). The C allele frequency of the LTA rs909253 T/C polymorphism was higher in AS cases than that in the controls (28.5% versus 19.7%, P=2×10-4) in Ningxia population. The results suggest that there is a relevance between LTA and the susceptibility of AS, and we identified that the LTA polymorphism may be associated with AS in Ningxia population.

摘要

据报道，淋巴毒素-α（LTA）基因与系统性红斑狼疮（SLE）、银屑病和类风湿性关节炎存在遗传关联。然而，LTA与强直性脊柱炎（AS）的关联尚未见报道。通过病例对照研究，我们对宁夏人群（300例病例和385例对照）约58 kb的HLA III类区域进行了高密度有限基因组扫描。在本研究中，对宁夏人群中LTA的33个单核苷酸多态性（SNP）进行了基因分型。我们分析了这些SNP以及覆盖LTA的单倍型。仅包含LTA rs909253突变等位基因的TCC单倍型分布具有统计学意义（P = 0.0005）。在宁夏人群中，AS病例中LTA rs909253 T/C多态性的C等位基因频率高于对照组（28.5%对19.7%，P = 2×10-4）。结果表明，LTA与AS易感性之间存在相关性，并且我们确定LTA多态性可能与宁夏人群的AS相关。