Department of Orthopaedics, The Jintan Hospital Affiliated to Jiangsu University, Changzhou, 213200, China.
Department of Orthopaedics, The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, Changzhou, 213003, China.
Sci Rep. 2020 Jan 29;10(1):1412. doi: 10.1038/s41598-020-57927-6.
Lymphotoxin-a (LTA) may be associated with the pathogenesis of inflammatory diseases. To assess the association of the LTA rs909253 A/G polymorphism with plasma level and risk of ankylosing spondylitis (AS) in a Chinese Han population. Genotyping and LTA plasma were tested by mass spectroscopy and enzyme-linked immunosorbent assay (ELISA), respectively. The results showed that the average plasma level of LTA in AS was significantly lower than in the controls (P = 0.000). Our results also indicated that LTA rs909253 A/G was associated with a decreased risk of AS (G vs. A: P = 0.014). Significant differences were also found between the rs909253 A/G genotype and down-regulated plasma level in AS patients, compared with controls. After stratification analysis, a decreased risk of AS was associated with the LTA rs909253 G allele (G vs. A) among female patients, younger patients (Yr. < 30), HLA-B27-positive patients. In addition, In conclusion, LTA rs909253 A/G genotype has a significant relationship with decreased susceptibility to AS.
淋巴毒素-α（LTA）可能与炎症性疾病的发病机制有关。为了评估 LTA rs909253 A/G 多态性与中国汉族人群血浆水平和强直性脊柱炎（AS）风险的关系。采用质谱法和酶联免疫吸附试验（ELISA）分别检测基因分型和 LTA 血浆。结果表明，AS 患者的 LTA 平均血浆水平明显低于对照组（P = 0.000）。我们的研究结果还表明，LTA rs909253 A/G 与 AS 风险降低相关（G 对 A：P = 0.014）。与对照组相比，AS 患者的 rs909253 A/G 基因型与下调的血浆水平之间也存在显著差异。分层分析后，LTA rs909253 G 等位基因（G 对 A）与女性患者、年轻患者（Yr. < 30）、HLA-B27 阳性患者的 AS 发病风险降低相关。总之，LTA rs909253 A/G 基因型与 AS 易感性降低有显著关系。
