Narayanaswamy Arun, Su Daniel H, Baskaran Mani, Tan Anna C S, Nongpiur Monisha E, Htoon Hla M, Wong Tien Y, Aung Tin
Glaucoma Service, Singapore National Eye Centre, 11 Third Hospital Ave, Singapore.
Arch Ophthalmol. 2011 Apr;129(4):429-34. doi: 10.1001/archophthalmol.2011.60.
To evaluate corneal hysteresis (CH) and intraocular pressure (IOP) measured by the Ocular Response Analyzer in Chinese subjects with primary angle-closure glaucoma (PACG), assess their relationship with Goldmann applanation tonometry (GAT) measurements, and compare this with subjects with primary open-angle glaucoma (POAG) and normal controls.
In this prospective observational study, consecutive subjects with PACG and POAG without prior intraocular surgery were enrolled from glaucoma clinics. Normal subjects were recruited from an ongoing population-based study. One eye of each subject underwent standardized ocular examination and IOP measurement by GAT and the Ocular Response Analyzer. Corneal hysteresis and corneal-compensated IOP were compared between groups.
Of the 443 subjects recruited, 131 had PACG, 162 had POAG, and 150 were normal. Corneal hysteresis was lower in PACG (9.1 mm Hg; 95% confidence interval [CI], 8.7 to 9.4 mm Hg) and POAG (9.5 mm Hg; 95% CI, 9.2 to 9.5 mm Hg) eyes compared with control eyes (10.4 mm Hg; 95% CI, 10.1 to 10.6 mm Hg; P < .001 for both), with no difference (P = .16) in CH found between PACG and POAG eyes. After adjusting for age, sex, and IOP measurement by GAT, CH persisted to be lower only in eyes with PACG in comparison with control eyes (9.4 vs 10.1 mm Hg; P = .006). Eyes with POAG had lower CH than control eyes but the difference was not statistically significant (9.6 vs 10.1 mm Hg; P = .06).
Corneal hysteresis was lower in eyes with glaucoma. After adjusting for age, sex, and IOP measurement by GAT, a persistently lower hysteresis was noted in eyes with PACG compared with other groups.
使用眼反应分析仪评估中国原发性闭角型青光眼（PACG）患者的角膜滞后（CH）和眼压（IOP），评估它们与Goldmann压平眼压计（GAT）测量值的关系，并与原发性开角型青光眼（POAG）患者和正常对照者进行比较。
在这项前瞻性观察研究中，从青光眼诊所招募了未接受过眼内手术的连续性PACG和POAG患者。正常受试者从一项正在进行的基于人群的研究中招募。每位受试者的一只眼睛接受了标准化眼科检查，并通过GAT和眼反应分析仪测量眼压。比较各组之间的角膜滞后和角膜补偿眼压。
在招募的443名受试者中，131例患有PACG，162例患有POAG，150例为正常对照。与对照眼（10.4 mmHg；95%置信区间[CI]，10.1至10.6 mmHg）相比，PACG眼（9.1 mmHg；95% CI，8.7至9.4 mmHg）和POAG眼（9.5 mmHg；95% CI，9.2至9.5 mmHg）的角膜滞后较低（两者P均<0.001），PACG眼和POAG眼之间的CH无差异（P = 0.16）。在调整年龄、性别和GAT测量的眼压后，与对照眼相比，仅PACG眼的CH持续较低（9.4 vs 10.1 mmHg；P = 0.006）。POAG眼的CH低于对照眼，但差异无统计学意义（9.6 vs 10.1 mmHg；P = 0.06）。
青光眼患者的角膜滞后较低。在调整年龄、性别和GAT测量的眼压后，与其他组相比，PACG眼的滞后持续较低。
