利比亚国家基本药物清单与世界卫生组织基本药物标准清单的比较分析。

A comparative analysis of the Libyan national essential medicines list and the WHO model list of essential medicines.

机构信息

Department of Pharmaceutics, Faculty of Pharmacy, Al-Arab Medical University, Benghazi, Libya.

出版信息

Libyan J Med. 2010 Dec 2;5. doi: 10.3402/ljm.v5i0.5403.

DOI:10.3402/ljm.v5i0.5403

PMID:21483564

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3066759/

Abstract

AIM AND OBJECTIVES

To examine the concordance of the Libyan Pharmaceutical List of Essential Medicines (LPLEM) with the World Health Organization Model List of Essential Medicines 2009 (WMLEM 2009).

METHODS

The concordance between generic medicines listed in the WMLEM 2009 (standard reference list) and the LPLEM 2006 (comparator list) was evaluated.

RESULTS

The total number of Basic Essential Medicines (BEMs) listed on the WMLEM 2009 was 347. The total number of generic medicines listed on the LPLEM was 584. Although the LPLEM has more listed medicines, only 270 (77.6%) of BEMs from the WMLEM were listed as available. However, 25 of the 77 missing medicines were deemed to have appropriate alternatives. A total of 52 medicines from the WMLEM 2009 were therefore missing from the LPLEM. Discrepancies compared to the WMLEM 2009 were identified in 15 out of 29 therapeutic sections. The highest discrepancy rate from the WMLEM 2009 was in the anti-infective section (35 missing medicines). Missing BEMs were noted in many subclassifications of the anti-infective medicines section, but omissions were particularly prevalent in the antibacterial medicines subsection (11 missing medicines). Antituberculosis medications had the highest discrepancy rate for antibacterial BEMs with one-third of the single medicines recommended by the WHO in the WMLEM 2009 not listed on the LPLEM. Of the 314 additional medicines on the LPLEM, 18 were deemed to be irrational non-essential medicines.

CONCLUSION

The LPLEM does not include several essential medicines recommended by the WHO in the WMLEM 2009. These discrepancies may have serious public health implications for management of some infectious diseases, particularly, tuberculosis and HIV.

摘要

目的

检查利比亚基本药物清单（LPLEM）与世界卫生组织 2009 年基本药物示范清单（WMLEM 2009）的一致性。

方法

评估 WMLEM 2009 中列出的通用药物（标准参考清单）与 LPLEM 2006 （比较清单）之间的一致性。

结果

WMLEM 2009 列出的基本必备药物（BEMs）总数为 347 种。LPLEM 列出的通用药物总数为 584 种。尽管 LPLEM 列出的药物更多，但只有 WMLEM 中的 270 种（77.6%）BEMs被列为可用。然而，77 种缺失药物中有 25 种被认为有适当的替代品。因此，WMLEM 2009 中有 52 种药物从 LPLEM 中缺失。与 WMLEM 2009 相比，29 个治疗部分中有 15 个存在差异。在抗感染药物部分，与 WMLEM 2009 的差异率最高（缺失 35 种药物）。在抗感染药物部分的许多亚分类中都注意到缺失的 BEMs，但在抗菌药物亚类中缺失尤为普遍（缺失 11 种药物）。抗结核药物在抗菌 BEMs 方面的差异率最高，WHO 在 WMLEM 2009 中推荐的三分之一单药未列入 LPLEM。LPLEM 上的 314 种其他药物中，有 18 种被认为是非必需的不合理药物。